BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Textbook Question
Chapter 42, Problem 3S
Describe the steps required to produce an excitatory postsynaptic potential (EPSP). How would these differ at an inhibitory synapse?
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Depression is a condition in which sufferers may feel low mood, lack of motivation and sleep. It is caused by a lack of serotonin in the synaptic cleft of neurone pathways. Serotonin is a neurotransmitter.
a) Describe how serotonin acts as a neurotransmitter. Using your understanding of synaptic transmission, explain how communication between neurones in serotonin pathways of the brain would be affected in someone with depression.
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Let’s say the synapses of a neuron’s dendrites are filled with glutamate-gated channels which, when activated by glutamate, cause an excitatory postsynaptic potential (EPSP) in the neuron. In one instance, glutamate is released at all of the synapses simultaneously and this leads to an action potential in the neuron.
A) What type of summation of PSPs is this? Why?
B) List the sequence of steps that occur starting from binding of glutamate to the glutamate-gated channels at the synapses and ending with the membrane potential at the axon hillock returning to resting potential at the end of the action potential. (Include all the changes in voltage-gated channels underlying the action potential.)
What type of synaptic potential (if any; be sure to indicate if any modification is occurring as well) would occur if:
a.) An MAO inhibitor type of antidepressant is functioning at an active dopaminergic synapse that increases the rate of sodium flowing into the cell.
b.) Prozac is present at an active serotonin synapse where receptor activation increases the flow of potassium out of the cell.
Chapter 42 Solutions
BIOLOGY
Ch. 42.1 - Differentiate between subdivisions of the...Ch. 42.1 - Prob. 2LOCh. 42.1 - Explain the roles of the different nervous system...Ch. 42.2 - Contrast the relative concentrations of important...Ch. 42.2 - Prob. 2LOCh. 42.2 - Prob. 3LOCh. 42.3 - Prob. 1LOCh. 42.3 - Prob. 2LOCh. 42.3 - Prob. 3LOCh. 42.4 - Prob. 1LO
Ch. 42.4 - Prob. 2LOCh. 42.4 - Prob. 3LOCh. 42.5 - Describe the organization of the peripheral...Ch. 42.5 - Prob. 2LOCh. 42.5 - Prob. 3LOCh. 42.5 - Prob. 4LOCh. 42 - Data analysis Draw the resulting potentials for...Ch. 42 - Prob. 2DACh. 42 - Which of the following best describes the...Ch. 42 - The ____ cannot be controlled by conscious...Ch. 42 - Prob. 3UCh. 42 - Inhibitory neurotransmitters a. hyperpolarize...Ch. 42 - White matter is ______, and gray matter is...Ch. 42 - During an action potential a. the rising phase is...Ch. 42 - Prob. 7UCh. 42 - Imagine that you are doing an experiment on the...Ch. 42 - The Na+/K+ ATPase pump is a. not required for...Ch. 42 - Prob. 3ACh. 42 - The following is a list of the components of a...Ch. 42 - Prob. 5ACh. 42 - As you sit quietly reading this sentence, the part...Ch. 42 - G proteincoupled receptors are involved in the...Ch. 42 - Tetraethylammonium (TEA) is a drug that blocks...Ch. 42 - Describe the status of the Na+ and K+ channels at...Ch. 42 - Describe the steps required to produce an...Ch. 42 - Prob. 4S
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- Which of the following statements concerning synapses is FALSE? O A) Modulation of synaptic strength can be presynaptic of postsynaptic B) High frequency stimulation in the presynaptic neuron often leads to DECREASED neurotransmitter release O C) Modulation of synaptic strength can either be short term, lasting seconds, or long term, lasting as long as a lifetime. D) Agonists are drugs that mimic neurotransmitters and antagonists are drugs that block the action of neurotransmitters O E) Certain drugs prevent the reuptake of neurotransmitter from the synapsearrow_forwardAssume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold. thanks a lot in advance:)arrow_forwardWhat is a post-synaptic potential and how is it caused? Describe the two types of post-synaptic potentials that can occur. Within this context, what does excitatory and inhibitory mean?arrow_forward
- Events at a chemical synapse usually involve opening both voltage-gated ion channels and chemically gated ion channels. Where are these ion channels located and what causes each to open?arrow_forwardWhat is inhibitory synapse ? Prepare the figure of inhibitorysynapse ?arrow_forwardWhen an impulse arrives at the synapse, the synaptic vesicles open and release neurotransmitters into the cleft within a thousandth of a second. Within another ten thousandth of a second, these molecules have diffused across the cleft and bound to receptor sites in the effector cell. In what two ways is transmission across a synapse terminated so that the neuron’s signal is concluded?arrow_forward
- What are the criteria for identification of the neurotransmitter at a particular synapse? Which two criteria are sufficient to conclude that a candidate substance is a neurotransmitter?arrow_forwardWhat is an electrical synapse? Where can electrical synapses be found? Identify an advantage and a disadvantage of an electrical synapse compared to a chemical synapse.arrow_forwardIn simple terms, explain the transmission of nerve impulse at the synapse.arrow_forward
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