Biology: Life on Earth with Physiology (11th Edition)
11th Edition
ISBN: 9780133923001
Author: Gerald Audesirk, Teresa Audesirk, Bruce E. Byers
Publisher: PEARSON
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Chapter 37.2, Problem 1CSC
If phagocytes kill most species of bacteria that enter mucous membranes or a wound, how did infection kill Jim Henson and destroy Aimee Copeland’s tissues? Both S pyogenes and deadly strains of A. hydrophila are surrounded by polysaccharide capsules that phagocytic cells often do not recognize as foreign. Consequently, the phagocytes do not attack these bacteria. If such nonspecific defenses fail, can the adaptive immune response step in?
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Mycobacteria are intracellular pathogens that have adapted to life inside phagocytic cells, such as macrophages. These intracellular bacteria are taken up by phagocytosis, similar to other pathogens, but the bacteria are not killed. One possible mechanism that could account for this immune evasion by mycobacteria is their ability to:
Prevent induction of nitric oxide production in the phagosome
Prevent the acidification of phagosomes
Prevent the expression of antimicrobial peptides in the phagosome
Prevent fusion of phagosomes with lysosomes
Kill the macrophage before it kills them
Draw a figure illustrating the sequence of events in a typical inflammatory response to a bacterial
infection caused by injury to the skin (in 3 main stages).
Include a note at top of figure: Is this an example of an innate response or adaptive immune response?
Include the following structures/cells/chemicals: epidermis, dermis, splinter contaminated with bacteria
puncturing skin, macrophages, mast cells, neutrophils, nitric oxide (as blue dots), endothelial cells lining
capillary, red blood cells within capillary, histamine (as green dots).
Under each stage, describe the events occurring in the 3 main stages:
Stage 1: What do mast cells and endothelial cells produce in initial response to injury? What do the
chemicals produced by the cells do?
Stage 2: What happens to capillaries? What leaks out of capillaries to enter the site of the wound?
Stage 3: What do neutrophils and macrophages do? What happens to capillaries at this point?
Chapter 37 Solutions
Biology: Life on Earth with Physiology (11th Edition)
Ch. 37.1 - compare and contrast the terms microbe and...Ch. 37.1 - Prob. 2CYLCh. 37.2 - If phagocytes kill most species of bacteria that...Ch. 37.2 - describe the external barriers to Infection,...Ch. 37.2 - Prob. 1TCCh. 37.2 - Prob. 2CYLCh. 37.3 - Prob. 1CYLCh. 37.3 - Prob. 2CYLCh. 37.4 - Prob. 1CYLCh. 37.4 - Prob. 2CYL
Ch. 37.4 - Prob. 3CYLCh. 37.5 - Prob. 1CYLCh. 37.5 - Prob. 2CYLCh. 37.6 - Prob. 1CYLCh. 37.6 - Prob. 2CYLCh. 37.7 - explain how antibiotics, antiviral drugs, and...Ch. 37.7 - Prob. 1ETCh. 37.7 - Prob. 1HYEWCh. 37.7 - Prob. 1TCCh. 37.7 - Prob. 2CYLCh. 37.8 - Prob. 1CYLCh. 37.8 - What might be the evolutionary advantage of...Ch. 37.9 - Prob. 1CSRCh. 37.9 - Prob. 1CTCh. 37.9 - Prob. 1CYLCh. 37.9 - describe current medical treatments against...Ch. 37 - Why is it essential that antibodies and T-cell...Ch. 37 - External defenses against microbial invasion...Ch. 37 - Prob. 1MCCh. 37 - Prob. 1RQCh. 37 - Prob. 2ACCh. 37 - Prob. 2FIBCh. 37 - Prob. 2MCCh. 37 - Prob. 2RQCh. 37 - Prob. 3FIBCh. 37 - Molecules that label your cells as self are a....Ch. 37 - Describe humoral immunity and cell-mediated...Ch. 37 - Prob. 4FIBCh. 37 - Prob. 4MCCh. 37 - Prob. 4RQCh. 37 - Prob. 5FIBCh. 37 - The immune system usually does not attack your...Ch. 37 - Prob. 5RQCh. 37 - Prob. 6FIBCh. 37 - Prob. 6RQCh. 37 - What are memory cells? How do they contribute to...Ch. 37 - Prob. 8RQCh. 37 - Prob. 9RQCh. 37 - Prob. 10RQCh. 37 - Prob. 11RQ
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- In Lubeck, Germany, in 1930, a group of 251 infants was accidentally administered a tainted vaccine for tuberculosis that contained live Mycobacterium tuberculosis. This vaccine was administered orally, directly exposing the infants to the deadly bacterium. Many of these infants contracted tuberculosis, and some died. However, 44 of the infants never contracted tuberculosis. Based on your knowledge of the innate immune system, what innate defenses might have inhibited M. tuberculosis enough to prevent these infants from contracting the disease?arrow_forward1) According to the video, what is another name for the innate immune sys and what does this system do? 2) According to the video, what causes inflammation and what cells cause it? 3) According to the video, what happens to neutrophils after they consume a pathogen? 4) According to the video, natural killer cells; what do they do? 5) The adaptive/acquired immune system can tell the difference between types of pathogens: true or false? 6) According to the video, helper t- function: 7) According to the video, cytotoxic t cells function: 8) According to the video, memory cells function:arrow_forwardOpsonization of pathogens by both antibodies and complement proteins (C3b) leads to uptake and destruction of the pathogen by phagocytic cells that express both Fc receptors and complement receptors. Which of the following in the figure below is the most efficient form of dual opsonization of the pathogen by antibody and C3b to maximize phagocytosis?arrow_forward
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