Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 36, Problem 13P
Interpretation Introduction
Interpretation:
The additional structure present in the KIF1A other than motor domain should be determined.
Concept introduction:
KIF1A is a motor protein. This protein is special as it moves only toward the positive end of the microtubules as a monomer. It has a motor domain which helps in its movement.
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Students have asked these similar questions
Shape and dimension. (a) Tropomyosin, a 70-kDa muscle protein, is a two-stranded α-helical coiled coil. Estimate the length of the molecule. (b) Suppose that a 40-residue segment of a protein folds into a two-stranded antiparallel β structure with a 4-residue hairpin turn. What is the longest dimension of this motif?
CENTRAL DOGMA & STRUCTURE-FUNCTION RELATIONSHIPS IN PROTEINS
You are a bacteriologist studying a pathogenic protein (the "BAD" protein) that contributes to diseases
caused by Staphylococcus aureus. BAD functions as an aß heterodimer, and the a subunit (25kD)
and ß subunit (75KD) are held together by an electrostatic interaction between K in the a subunit and
D in the B subunit.
You are trying to dissociate the BAD subunits to prevent pathogenesis in the bacteria. Which
mutation would you make to prevent the BAD subunits from forming a dimer? Assume neutral pH.
(A) introduce AAA → AGA point mutation in the a subunit gene
(B) introduce GAC → GAG point mutation in the ß subunit gene
(C) introduce GAT → CGT point mutation in the ß subunit gene
(D) introduce two point mutations: AAG → GTG in the a subunit gene & GAC → CTC in the B subunit
gene
(E) introduce two point mutations: AAA → TGC in the a subunit gene & GAT → TGT in the B subunit
gene
second base in codon
A
TGT Cys
TGC Cys
TTT Phe…
7 Protein structure.Circle one of the three amino acid sequences that is most likely to
form a stable a-helix?
RASKTARQ
DASKTAEQ
KPGKPAGQ
In one sentence (that can be accompanied by a small picture) explain why?
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