Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 34, Problem 7CHI
Summary Introduction
The vaccine is defined as a biological preparation (disease-causing agent) which increases immunity to a particular disease or several diseases. Vaccination is the administration of a vaccine to assist the defense mechanism to develop protection against disease. A subunit vaccine is a vaccine that includes only the limited microbial elements, which is needed to induce a long-lasting immune response.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
The current view in the field of immunology is that dendritic cells are the primary antigen-presenting cells for stimulating naive T cells. One piece of evidence supporting this conclusion is the observation that IRF8-deficient individuals, which retain their tissue-resident macrophages, are susceptible to a range of severe opportunistic infections caused by intracellular bacteria, viruses, and fungi. Explain the reasoning behind this argument.
When vesicular stomatitis virus (VSV) is used to infect mice via footpad injection, viral particles are trapped in the draining lymph node (the popliteal lymph node) within 5 minutes of injection. These viral particles are then retained in the lymph node for many hours, where they can be visualized on cells that are interacting with B cells. The cells retaining the viral particles in the lymph node are not tissue-resident dendritic cells that have migrated to the lymph node with the virus, as this process takes much longer than 5 minutes. In which region of the lymph node would you expect to find the trapped viral particles and on which cells?
Surprisingly, humans as well as mice deficient in the complement protein, C3, have greatly reduced antibody responses to T cell-dependent antigens, and are impaired in their ability to control HSV infections. When C3-deficient mice are infected with HSV, once at day 0 and then a second time 4 weeks later, their antibody response is altered compared to wild-type mice, as shown in the figure #3 below.
a) What is a likely explanation for the altered antibody response in the absence of complement C3?
For fugure #4: For this experiment, mice are infected with varying doses of the HSV-rd virus, and peak IgG responses to the viral surface glycoproteins are measured. The results are shown in the fugure #4.
b) What is the most likely explanation for these data? Do these results impact your answer to the part above (a)? Explain your reasoning.
Chapter 34 Solutions
Prescott's Microbiology
Ch. 34.2 - What does the term valence mean and how does an...Ch. 34.2 - Distinguish between self and nonself substances.Ch. 34.2 - Prob. 2RIACh. 34.2 - How does a hapten differ from an antigen?Ch. 34.3 - What are the types of adaptive immunity?Ch. 34.3 - What distinguishes natural from artificial...Ch. 34.3 - What are ways that active immunity is different...Ch. 34.3 - Of the four types of acquired immunity, which do...Ch. 34.4 - On what types of cells are MHC class I molecules...Ch. 34.4 - Prob. 2MI
Ch. 34.4 - What are MHCs and HLAs? Describe the roles of the...Ch. 34.4 - Prob. 2RIACh. 34.4 - Prob. 3RIACh. 34.4 - How are foreign peptides processed so as to...Ch. 34.5 - Prob. 1MICh. 34.5 - Prob. 1RIACh. 34.5 - Prob. 2RIACh. 34.5 - Describe antigen processing. How does this process...Ch. 34.5 - Prob. 4RIACh. 34.5 - Prob. 5RIACh. 34.5 - Prob. 6RIACh. 34.6 - Which cells are functioning as APCs in this...Ch. 34.6 - Prob. 1RIACh. 34.6 - Briefly compare and contrast B cells and T cells...Ch. 34.6 - Prob. 3RIACh. 34.6 - Prob. 4RIACh. 34.7 - Prob. 1MICh. 34.7 - Prob. 2MICh. 34.7 - Prob. 3MICh. 34.7 - Prob. 1.1RIACh. 34.7 - Prob. 1.2RIACh. 34.7 - Prob. 1.3RIACh. 34.7 - Prob. 1.4RIACh. 34.7 - Prob. 2.1RIACh. 34.7 - Prob. 2.2RIACh. 34.7 - Prob. 2.3RIACh. 34.7 - Prob. 2.4RIACh. 34.7 - Prob. 2.5RIACh. 34.7 - Prob. 3.1RIACh. 34.7 - Prob. 3.2RIACh. 34.7 - In addition to combinatorial joining, what other...Ch. 34.8 - What is the difference between a precipitation and...Ch. 34.8 - Prob. 1RIACh. 34.8 - Prob. 2RIACh. 34.8 - How does opsonization inhibit microbial adherence...Ch. 34.8 - Prob. 4RIACh. 34.9 - Prob. 1RIACh. 34.9 - How would you define anergy?Ch. 34.10 - Prob. 1MICh. 34.10 - Prob. 2MICh. 34.10 - Prob. 1.1RIACh. 34.10 - Prob. 1.2RIACh. 34.10 - Prob. 1.3RIACh. 34.10 - Prob. 1.4RIACh. 34.10 - Prob. 1.5RIACh. 34.10 - What is an autoimmune disease and how might it...Ch. 34.10 - Prob. 2.2RIACh. 34.10 - Prob. 2.3RIACh. 34.10 - Prob. 2.4RIACh. 34 - What properties of proteins make them suitable...Ch. 34 - What other biotechnologies could be invented based...Ch. 34 - Speculate as to how MHC, TCR, and BCR molecules...Ch. 34 - Prob. 4CHICh. 34 - Prob. 5CHICh. 34 - In an effort to better understand the mechanisms...Ch. 34 - Prob. 7CHI
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A flu-infected cell has down-regulated its MHC class I expression. The lymphocytes below comes to the site and interacts with the cell. How does the downregulation of MHC class I affect these ability of lymphocytes to kill the infected cell? a) influenza-specific T cell b) NK cell c) herpes-specific T cell Indicate whether the possibility increases, decreases or is unchanged for each cell.arrow_forwardYou are investigating a case of SCID in which you have observed that the diversity of both T- and B- cells (that is, diversity of both the TCRS and BCRS on the cells of this patient) is drastically reduced. List two genes whose mutation could produce this result, and briefly explain what each one's product normally does.arrow_forwardInfluenza virus causes serious disease and death, and is responsible for one of the largest pandemics in recorded history. However, the process by which antigens are made and processed are not unique to that virus. Answer the following questions to trace how infected cells will become recognizable by the TCR of a compatible T-cell. A) Where are the viral proteins made? B) Describe the process by which viral proteins are broken down into peptides. Be sure to discuss any unique molecules or organelles that participate in the process. C) Which MHC molecule presents these peptides? D) Now that you have made peptides from the viral antigen, how do they get to and bind to the MHC molecule? Describe the process. What unique molecules are involved in this process? E) What is the final destination for these molecules/epitopes, and how do they reach that destination?arrow_forward
- Borrelia hermsii is a spirochete bacterium, transmitted by tick bites, that causes an illness characterized by a relapsing fever. The bacteria enter the host bloodstream and replicate there. Studies in mice show that episodes of bacteremia (bacteria in the blood) are efficiently controlled by anti-bacterial antibodies, but interestingly, follicular B cells are not required for this response, nor is the response impaired by splenectomizing the mice (i.e., removing the spleen). Which B cells are most likely responsible for this antibody response?arrow_forwardWhich of the followings is molecular pathology associated with ADA mutations that cause immunodeficiency? a) accumulation of deoxyadenosine and its precursors S-adenosylhomocysteine and deoxyadenosine triphosphate (dATP) with toxic effects on immature lymphocytes, b)accumulation of deoxyguanosine and deoxyguanosine triphosphate, with toxic effects on immature lymphocytesarrow_forwardSecondary lymphoid organs (SLOs) are important sites for the initiation of T cell responses via immune priming. Once an antigen-presenting cell (APC) presenting peptide-MHC arrives at a secondary lymphoid organ, it must find a relatively rare T cell clone with a TCR that recognizes its presented peptide-MHC complex. Which of the following features of SLOs increases the likelihood of this APC finding its cognate T cell? Activated APCs are captured by SLO-resident macrophages once they enter via afferent lymphatics, allowing them to be interrogated by T cells Concentrate high densities of T cells within specific zones to enable efficient APC browsing Drain pathogens from infected tissues through the lymphatics, bringing them to secondary lymphoid organs where they can be killed by B cells Contain specialized nutrients that are required for productive TCR signaling following interactions with a cognate APCarrow_forward
- 1:Describe the various stages of T cells and the events that occur during each of these stages during T cell development. What stages of T cell development would be affected in mice with the following genetic mutations? Justify your answer. a) Mice that do not express MHC Class I molecule. b) Mice that do not express Rag1 c) Mice that do not express the pre-T-alpha chain 2:Transgenic mice that have constitutive expression of Rag1/2 are being used in an experiment to study pre-BCR signaling. Based on your knowledge of early B cell development, speculate on what might be the fate of BCR rearrangement and how will this affect further development of B cells in the bone marrow? please answer in full detail I want long well explained answers.arrow_forwardPlease could you explain how lymphocytes (especially B) can maintain receptors on their surfaces? Is this genetically related? If so, when the lymphocytes are first exposed to the antigens, how could the antigen receptor be synthesized? Is there a mutation within the nuclei of these lymphocytes when they learn to make the receptors? If there is, can you explain how this occurs?arrow_forwardPatients with recurrent infections of Neisseria meningitidis, an extracellular bacterial pathogen that causes meningitis, were examined to determine the underlying cause of their immunodeficiency. A subset of these patients were found to have defects in complement activation on the bacterial surface, a process that for this bacterium is dominated by alternative complement activation leading to C3b deposition on the pathogen surface. When neutrophils from these patients were examined in vitro, the results, in the figure below, were obtained. Based on these data, the identity of the green neutrophil mediator in the figure below is likely to be: Complement factor B The C3 convertase Factor P (properdin) C3b Mannose-binding lectin (MBL)arrow_forward
- Some pathogenic microorganisms encode proteins, such as the Staphylococcus Protein A, that bind to immunoglobulin constant region domains with high affinity. These microbial proteins provide a benefit to the microorganism by: Preventing antibodies bound to the microbe from binding to Fc receptors on phagocytes Blocking the binding of anti-microbial antibodies to the pathogen surface Cleaving the antibody into fragments that separate the antigen-binding region from the effector function Inducing aggregation of the anti-microbial antibodies by multivalent binding to the pathogen-derived protein Preventing the antibody from neutralizing the pathogenarrow_forwardYou are in the process of developing a monoclonal antibody against an Influenza virus spike protein "H7." You have isolated the B cells producing antibodies against the viral H7 protein and fused those specific B cells with a unique kind of mutant myeloma cells. The myeloma cells can't make any of the three following enzymes; dihydrofolate reductase (DHFR), thymidine kinase (TK), and hypoxanthine-guanosine phosphoribosyl transferase (HGPRT). The mutant unfused myeloma cells are grown in the laboratory in a nucleotide supplemented medium. For selecting the hybridomas, you have used a modified medium HT that does not contain any aminopterin but contains hypoxanthine and thymidine. Which of the following result do you expect to see from your experiment, and what problem you may encounter in the future after the hybridoma selection?arrow_forwardA pathogenesis function f(t)t(t-21)(t + 1) is used to model the development of the disease, where t is measured in days and f(t) represents the number of infected cells per mL of plasma. What is the peak infection time for this virus? (Round your answer to one decimal place.) t= Need Help? X days Read Itarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License