BIOCHEMISTRY
9th Edition
ISBN: 2818440090622
Author: BERG
Publisher: MAC HIGHER
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Chapter 33, Problem 4P
Interpretation Introduction
Interpretation:
The mechanism for the activation of DNA by 5-azacytidine should be explained.
Concept introduction:
5-Azacytidine is an analog of cytidine, which is a nucleoside. This chemicaland its deoxygenated analogdecitabine is used to treat myelodysplastic syndrome. High dosage of 5-azacytidine can cause anemia, thrombocytopenia, and neutropenia.
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Required partner. Aminotransferases require which of the following
cofactors:
a. NAD+/NADP+NAD+/NADP+
b. Pyridoxal phosphate
c. Thiamine pyrophosphate
d. Biopterin
Not hand written please.
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