Biochemistry: Concepts and Connections
Biochemistry: Concepts and Connections
1st Edition
ISBN: 9780321839923
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 3, Problem 7P

Assume that some protein molecule, in its folded native state, has one favored conformation. But when it is denatured, it becomes a “random coil,” with many possible conformations.
a. If we only consider the entropy for the protein, what must be the sign of Δ S for the charge native denatured? (Note: As suggested in the next problem, this does not include solvent effects, which also make contributions to Δ S.)
b. How will the contribution of Δ S for native denatured affect the favorability of the process? What apparent requirement does this impose on Δ H if proteins are to be stable structures?

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Assume that some protein molecule, in its folded native state, has onefavored conformation. But when it is denatured, it becomes a “random coil,” with many possible conformations.(a) If we only consider the change in entropy for the protein, what mustbe the sign of ΔS for the change: native → denatured? (Note: As suggestedin the next problem, this does not include solvent effects, which also make significant contributions to ΔS.)(b) How will the contribution of ΔS for native → denatured affect thefavorability of the process? What apparent requirement does this imposeon ΔH if proteins are to be stable structures?
The dissociation constant, Kd for a complex between protein A and protein B is 4.1 μM. If the two proteins are mixed together at initial concentrations of [A]= 0.025 μM and [B] = 4.7 μM, calculate (a) the equilibrium concentrations of A, B, and AB (the dimer formed by A and B) (b) the percentage of A bound to B
Suppose you have a mixture of the following proteins protein A: pl = 3.5, mw = 35 kDa protein B: pl = 5.5, mw = 22 kDa protein C: pl = 7.5, mw = 77 kDa protein D: pl = 9.0; mw = 52 kDa. Which protein do you expect to elute last if you perform separation using cation exchange chromatography at pH 7.0? A B Oc
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