EBK ORGANIC CHEMISTRY-PRINT COMPANION (
EBK ORGANIC CHEMISTRY-PRINT COMPANION (
4th Edition
ISBN: 9781119776741
Author: Klein
Publisher: WILEY CONS
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Chapter 3, Problem 74IP
Interpretation Introduction

Interpretation:

Most acidic protons needed to be found in the given anti-viral drug rilpivirine.

Concept introduction:

Acidic strength of the molecule depends on the stability of the Conjugate anion.

  • If the conjugate anion is more resonance stabilized, the acid considered as strong acid, the anion is weak base and the removed proton considered as a strong acidic proton.
  • If the negative charge present in the structure is more delocalized and stabilized by more number of atoms (electronegative), then the corresponding proton considered as more acidic proton.

To give: the two most acidic protons in the antiviral drug, and give the most acidic between them.

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