Campbell Biology
Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 28.6, Problem 4CC

MAKE CONNECTIONS Ø The bacterium Wolbachia is a symbiont that lives in mosquito cells and spreads rapidly through mosquito populations. Wolbachia can make mosquitoes resistant to infection by Plasmodium; researchers are seeking a strain that confers resistance and does not harm mosquitoes. Compare evolutionary changes that could occur if malaria control is attempted using such a Wolbachia strain versus using insecticides to kill mosquitoes. (Review Figure 28.16 and Concept 23.4.)

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Wolbachia is a genus of bacteria that infect cells of invertebrates. Surveys have found that up to a fifth of insect species have at least some individuals infected with Wolbachia. Pathogen or parasite? This endosymbiont (a symbiont that lives inside its host) bacteria can have many effects on its host, including killing offspring and changing the sex of offspring. Ary Hoffmann from the University of Melbourne in Australia, Michael Turelli from the University of California at Davis, and their associates have been studying Wolbachia infections in populations of Drosophila simulans from California. From the initial infection around 1980, Wolbachia infection spread northward across the state during the 1980s and 1990s. The most striking manifestation of infection in this fly species is cytoplasmic incompatibility: offspring produced in crosses where males are infected and the females are uninfected tend to die early in development. In crosses between infected males and infected females,…
Give typing answer with explanation and conclusion  In thinking about the clinical application of phylogenetics, discuss the role of phylogenetics in these areas.   a) Predictions of drug resistance   b) Identifying the origin of an outbreak   c)Predicting the spread of a disease
Phylogenetic with branch lengths scaled in genetic distance 0.88 0.88 0.93 0.78 2388-3883 232 2002 4⁹29930 9823-2883 0.8 0.82 0.89- Mycobacterium tuberculosis Lineage 2 0.99 2001 90-2004 4484 2005 -0.635 388627805 718356883 11 2002 -83331-9811 74333-2690 $250-2010 10737 2002 203 2001 1511 208201 4701810 2008-2011 6295 29889 8073_2007 0.01 (# substitutions/nucleotide site) 83922889 015 2005 98507_2009 8195 200 46828000 Root-to-tip distance Evolutionary distance from root-to-tip versus sampling time 2.8x10 2.2x10 R²=0.00 1990 1995 2000 00 000 80 2005 000 O oo XBOO8 1. In this figure you can see a phylogenetic tree of samples of Mycobacterium tuberculosis lineage 2 and a corresponding root-to-tip plot. The branch lengths in the tree are scaled by evolutionary/genetic distance, so not by time. In the plot on the right, the summed branch lengths going from the root to the tips of the trees are then plotted against the dates the tips were sampled. What can we conclude from these figures? The…

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