(a)
Interpretation:
The structure of quinine in
Concept introduction:
Aliphatic
Answer to Problem 26.33AP
The structure of quinine in
Explanation of Solution
When quinine reacts with
Figure 1
The structure of quinine in
(b)
Interpretation:
The structure of nicotine in
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by
Answer to Problem 26.33AP
The structure of nicotine in
Explanation of Solution
When nicotine reacts with
Figure 2
The structure of nicotine in
(c)
Interpretation:
The structure of tryptamine in
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by
Answer to Problem 26.33AP
The structure of tryptamine in
Explanation of Solution
The aliphatic amine present on the side chain of tryptamine gets protonated in
Figure 3
The structure of tryptamine in
(d)
Interpretation:
The structure of
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by
Answer to Problem 26.33AP
The structure of
Explanation of Solution
In the structure of
Figure 4
The structure of
(e)
Interpretation:
The structure of
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by
Answer to Problem 26.33AP
The structure of
Explanation of Solution
In
Figure 5
The structure of
(f)
Interpretation:
The structure of
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by
Answer to Problem 26.33AP
The structure of
Explanation of Solution
In
The formation of conjugated acid of
Figure 6
The structure of
(g)
Interpretation:
The structure of imitanib in
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by
Answer to Problem 26.33AP
The structure of imitanib in
Explanation of Solution
In imitanib, the aliphatic amine will be protonated than aromatic amine since the basicity of aliphatic amines is more. The aliphatic amine present adjacent to the methyl group will be protonated as it is electron rich due to the
Figure 7
The structure of imitanib in
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Chapter 26 Solutions
EBK ORGANIC CHEMISTRY
- (a) (From benzene)arrow_forwardOutline syntheses of each of the following from aniline and any necessary organic or inorganic reagents. (a) p-Nitroaniline (b) 2,4-Dinitroaniline (c) p-Aminoacetanilidearrow_forward(b) Distinguish each as aromatic or antiaromatic in terms of electronic basis. Explain which one is more stable. (i) Compound A Compound B (ii) Compound C Compound D (iii) Compound E Compound Farrow_forward
- (a) Highlight four significant reasons why porphyrin derivatives are a popular Ochoice as photosensitizers in photo- thermal cancer therapy.arrow_forwardHow would you account for the following :(a) Electrophilic susbstitution in case of aromatic amines takes place more readily than benzene.(b) Ethanamide is a weaker base than ethanamine.arrow_forwardAnswer ALL parts of this question. (a) Using resonance structures, discuss the following statement; phenols are much stronger acids than aliphatic alcohols. (b) Give the structure of a stronger organic acid than phenol. (c) Rationalise the acidity of the latter organic acid by drawing two resonance structures of the conjugate base. (d) Eugenol is a natural product derived from the dried flower buds of the evergreen tree, Eugenia aromatica. Briefly describe a procedure with reagents required to extract eugenol as a single component from the mixture of compounds present in these flower buds. OH LOCH 3 eugenolarrow_forward
- (b) Suggest a reasonable biosynthesis for the naturally occurring alkaloid coniine (isolated from hemlock), starting from octanoic acid. Coniinearrow_forwarda.) Rank the attached compounds in order of increasing acidity. (b)Which compound forms the strongest conjugate base?arrow_forward(a) Which is more reactive towards Electrophilic aromatic substitution (EAS)? (b) Which of the following is a a meta-substituted compound? (c) Which is the least reactive towards Electrophilic aromatic substitution (EAS)? (d) Which is an ortho-substituted compound?arrow_forward
- A)Which of these compounds (i and ii) are the weaker base.. B)Why would you suggest soarrow_forwardAnswer ALL parts of this question. (a) Compound Z is a tertiary aromatic amine with the formula, C8H11N. Provide a chemical structure for compound Z. (b) Provide a reaction scheme for the preparation of nitrous acid. (c) Draw the structure of the product formed exclusively when nitrous acid reacts with Z. (d) Give a curly arrow mechanism for the preparation of the yellow azo-dye from the reaction of Z with benzenediazonium chloride.arrow_forward3) Draw equations of the following reactions and and explain to which direction is the respective quillibrium shifted. a) cyclohexylamine + water b) aniline + sulphuric acid c) triethylamine + acetic acidarrow_forward
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