Organic Chemistry
12th Edition
ISBN: 9781118875766
Author: T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder
Publisher: WILEY
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Question
Chapter 25, Problem 8PP
Interpretation Introduction
Interpretation:
The intermediate formed during the conversion of adenine to hypoxanthine, hydrogen bonds of hypoxanthine-cytosine base pair and the consequences it would have through two rounds of DNA (deoxyribonucleic acid) replication is to be shown.
Concept Introduction:
▸ Normally, in DNA, adenine pairs with thymine by forming two hydrogen bonds. On treatment with nitrous acid, amino group of adenine undergoes changes to form diazonium and finally gets removed.
▸ Hypoxanthine forms two hydrogen bonds with cytosine instead of thymine. This mispairing then passes on to the daughter DNA formed during replication and further brings about permanent changes (mutations).
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1. How does real-time polymerase chain reaction work? 2. What does the melting point represent?
Which statement best explains the chemical differencesbetween DNA and RNA? (a) DNA has two different sugarsin its sugar–phosphate backbone, but RNA only has one.(b) Thymine is one of the DNA bases, whereas RNA’s correspondingbase is thymine minus a methyl group. (c) TheRNA sugar–phosphate backbone contains fewer oxygenatoms than DNA’s backbone. (d) DNA forms double helicesbut RNA cannot.
During base excision repair, DNA glycosylase cleaves theN-glycosidic link between the altered base and the deoxyribose component of the nucleotide. Draw a typical nucleotideand indicate which bond is cleaved.
Chapter 25 Solutions
Organic Chemistry
Ch. 25 - Prob. 1PPCh. 25 - Prob. 2PPCh. 25 - Prob. 3PPCh. 25 - Prob. 4PPCh. 25 - Prob. 5PPCh. 25 - Practice Problem 25.6 (a) There are approximately...Ch. 25 - Prob. 7PPCh. 25 - Prob. 8PPCh. 25 - Prob. 9PPCh. 25 - Practice Problem 25.10
The sense strand of a...
Ch. 25 - Practice Problem 25.11
(a) Using the first codon...Ch. 25 - Write the structure of the RNA dinucleotide GC in...Ch. 25 - 25.13 Write the structure of the DNA dinucleotide...Ch. 25 - The example of a silylHilbertJohnson...Ch. 25 - Prob. 15PCh. 25 - Prob. 16PCh. 25 - Research suggests that expression of certain genes...
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Similar questions
- Suppose that 28% of the nucleotides in a DNA molecule are deoxythymidine 5'-monophosphate, and that during DNA replication the percentage amounts of available nucleotide bases art 22% A, 22% C, 28% G. and 28% T. Which base would be depleted first in the replication process?arrow_forwardOn complete hydrolysis, a polypeptide gives two alanine, one leucine, one methionine, one phenylalanine, and one valine residue. Partial hydrolysis gives the following fragments: Ala-Phe, Leu-Met, Val-Ala, Phe-Leu. It is known that the first amino acid in the sequence is valine and the last one is methionine. What is the complete sequence of amino acids?arrow_forwardSuppose that 30% of the nucleotides in a DNA molecule are deoxyguanosine 5'- monophosphate, and that during DNA replication the percentage amounts of available nucleotide bases are 20% A, 20% C. 30% G. and 30% T. Which base would be depleted first in the replication process?arrow_forward
- 22-42 (a) How many atoms of the peptide bond lie in the same plane? (b) Which atoms are they?arrow_forward22-20 Show how alanine, in solution at its isoelectric point, acts as a buffer (write equations to show why the pH does not change much if we add an acid or a base).arrow_forwardThe -chain of hemoglobin is a protein that contains 146 amino acids residues. What minimum number of nucleotides must be present in a strand of mRNA that is coded for this protein?arrow_forward
- Write ionic equations to show how serine acts as a buffer against the following added ions: a.OH b.H3O+arrow_forwardIs the trinucleotide in Problem 22-32 found only in DNA, found only in RNA, or found in both DNA and RNA? Explain the basis for your answer.arrow_forwardDraw Fisher projections representing the D and L forms of the following: a.aspartate b.phenylalaninearrow_forward
- 22-48 How many amino acid residues in the A chain of insulin are the same in insulin from humans, cattle (bovine), hogs, and sheep?arrow_forwardA mutational change alters a polypeptide by substitutingthree adjacent prolines for three glycines. What possibleeffect will this event have on the protein’s structure?arrow_forwardWhat amino acid does each abbreviation stand for? (a) Phe (b) Ser (c) Asp (d) Gln (e) His (f) Gly (g) Tyrarrow_forward
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