(a)
To determine: The use of Strecker synthesis to make phenylalanine.
Interpretation: The use of Strecker synthesis to make phenylalanine is to be shown.
Concept introduction: Strecker synthesis is a two step procedure that is used to synthesize alpha amino acids from
(b)
To determine: A mechanism for each step in the synthesis in part (a).
Interpretation: A mechanism for each step in the synthesis in part (a) is to be proposed.
Concept introduction: Strecker synthesis is a two step procedure that is used to synthesize alpha amino acids from aldehydes using a metal cyanide, acid catalyst and water. In first step, condensation of ammonia takes place with aldehyde to form an imine. It is followed generally by hydrolysis to
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Organic Chemistry (9th Edition)
- Show how you will use Strecker's synthesis to prepare phenylalanine in the laboratoryarrow_forwardThe amino group on aniline is an activator. Explain why the following reaction yields the meta product instead of the ortho and para productsarrow_forwardWhat carbonyl and nitrogen compounds are needed to make attached compound by reductive amination? When more than one set of starting materials is possible, give all possible methods.arrow_forward
- The reaction of an ester with an amine is not as slow as the reaction of an ester with water or an alcohol. Explain with reason. Explain why the rate of aminolysis of an ester cannot be increased by H+, OH- or OR-. How can you activate the carboxylic acid? Is acid catalyzed hydrolysis of acetamide a reversible or an irreversible reaction. Explain.arrow_forwardDraw the detailed mechanism of the synthesis of sertraline by arrow dragarrow_forwardShow how you would use a Strecker synthesis to make phenylalanine.arrow_forward
- Show how you will useModified Gabriel’s Synthesis and Streckers’s Synthesis to prepare phenylalanine in the laboratory.arrow_forwardPlease draw the mechanism for the synthesis of Acetanilide with Aniline and Acetic Anhydride.arrow_forwardShow how the m-hydroxybenzoic acid can be synthesized from benzene:arrow_forward
- Show how you can synthesize the following tertiary amine three different ways, each using a different secondary amineand adding the final substituent by(a) reductive amination (3 ways). (b) acylation–reduction (3 ways).arrow_forwardThe final steps in the Edman degradation result in rearrangement of a thiazolinone to an N-phenylthiohydantoin.Draw a stepwise mechanism for this acid-catalyzed reaction.arrow_forwardUsing a curved fish hook arrow, propose a mechanism for the reaction:arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning