Chapter 20.7, Problem 16P

Interpretation Introduction

Interpretation:

The difference in the boiling point of imidazole and $\text{N-methylimidazole}$ has to be explained.

Concept Introduction:

Imidazole is the aromatic compound and also the heterocyclic ring of histidine. It exists in both protonated and non-protonated form at $\text{pH}=7.4$. The lone pair on first nitrogen are a part of the pi cloud as they are present in p orbital whereas the lone pair electrons on third nitrogen are not a part of pi cloud because they are perpendicular to the p orbitals.