HUMAN BIOLOGY
16th Edition
ISBN: 9781260233032
Author: Mader
Publisher: RENT MCG
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Chapter 20.1, Problem 2CYP
Describe how mutations in tumor suppressor genes and proto-oncogenes regulate the cell cycle.
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Describe how the tumor-suppressor genes Rb, p53 and p21 regulate the cell cycle.
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Chapter 20 Solutions
HUMAN BIOLOGY
Ch. 20.1 - Descrihe the characteristics of cancer cells that...Ch. 20.1 - Prob. 2LOCh. 20.1 - Prob. 3LOCh. 20.1 - Prob. 1BTSCh. 20.1 - Prob. 2BTSCh. 20.1 - List the characteristics of cancer cells that...Ch. 20.1 - Describe how mutations in tumor suppressor genes...Ch. 20.1 - Prob. 3CYPCh. 20.2 - Prob. 1LOCh. 20.2 - Prob. 2LO
Ch. 20.2 - Summarize how protective behaviors and diet can...Ch. 20.2 - Prob. 1BTHCh. 20.2 - Prob. 2BTHCh. 20.2 - Prob. 1CYPCh. 20.2 - List the environmental carcinogens that are known...Ch. 20.2 - Prob. 3CYPCh. 20.3 - Prob. 1LOCh. 20.3 - Prob. 2LOCh. 20.3 - Prob. 1CYPCh. 20.3 - Identify the routine screening tests that are...Ch. 20.3 - Prob. 3CYPCh. 20.4 - Prob. 1LOCh. 20.4 - Prob. 2LOCh. 20.4 - Describe the three types of therapy that are...Ch. 20.4 - Discuss why cancer treatment may involve a...Ch. 20.4 - Prob. 3CYPCh. 20 - Prob. 1ACh. 20 - Prob. 2ACh. 20 - Angiogenesis stimulates the development of new...Ch. 20 - Prob. 4ACh. 20 - 5. Concerning the causes of cancer, which one is...Ch. 20 - Prob. 6ACh. 20 - Prob. 7ACh. 20 - Prob. 8ACh. 20 - Prob. 9ACh. 20 - Prob. 10ACh. 20 - Prob. 1TCCh. 20 - Prob. 2TCCh. 20 - Prob. 3TCCh. 20 - Prob. 4TCCh. 20 - Prob. 5TC
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- What is the difference between a proto-oncogene and a tumor-suppressor gene?arrow_forwardDefine tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forwardApart from p53, mention and describe the function of three tumor suppressor genes you knowarrow_forward
- What is the working of Tumor suppressor genes ?arrow_forwardDefine oncogene, proto-oncogene, and tumor-suppressor gene.arrow_forwardDiscuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.arrow_forward
- Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forwardDefine tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forwardWhat is a primary function of tumor suppressor genes?arrow_forward
- How tumor-suppressor genes contribute to cancer whenmutated or abnormally expressed ?arrow_forwardExplain in detail two different genetic mutations that can promote the development of cancer. Include the name (or type) of gene mutated and whether the expression of the gene is upregulated or downregulated. Provide a description of the role the gene plays in regulating the cell cycle and how the cell is affected when the gene no longer produces a functional proteinarrow_forwardThe p53 gene encodes a tumor-suppressor protein, p53, which acts as a transcription factor for several genes. Discuss an example of a specific gene that is activated by p53 and how this gene activation will lead to a pause in the cell cycle for DNA repair to take place.arrow_forward
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