Chapter 20, Problem 20.43P

Interpretation Introduction

(a)

Interpretation:

Synthesis of the given amine from an alkyl halide via Gabriel synthesis is to be shown.

Concept introduction:

The Gabriel synthesis is an effective way to synthesize a primary amine (${\text{RNH}}_2$) from an alkyl halide. In Gabriel synthesis, phthalimide is first treated with a strong base such as potassium hydroxide, followed by an alkyl halide. Subsequent hydrolysis using hydroxide then liberates the primary amine. The alkyl halide used would be analogous to the primary amine target.

Interpretation Introduction

(b)

Interpretation:

Synthesis of the given amine from an alkyl halide via a Gabriel synthesis is to be shown.

Concept introduction:

The Gabriel synthesis is an effective way to synthesize a primary amine (${\text{RNH}}_2$) from an alkyl halide. In Gabriel synthesis, phthalimide is first treated with a strong base such as potassium hydroxide followed by an alkyl halide. Subsequent hydrolysis using hydroxide then liberates the primary amine. The alkyl halide used would be analogous to the primary amine target.

Interpretation Introduction

(c)

Interpretation:

Synthesis of the given amine from an alkyl halide via Gabriel synthesis is to be shown.

Concept introduction:

Gabriel synthesis is an effective way to synthesize a primary amine (${\text{RNH}}_2$) from an alkyl halide. In Gabriel synthesis, phthalimide is first treated with a strong base such as potassium hydroxide followed by an alkyl halide. Subsequent hydrolysis using hydroxide then liberates the primary amine. The alkyl halide used would be analogous to the primary amine target.