Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 20, Problem 18P
Interpretation Introduction

Interpretation:

Pertussis toxin ADP ribosylates the a subunit of Gi. To explain how this toxin affects blood pressure.

Concept Introduction:

Pertussis toxin catalyzes the ADP-ribosylation of the ai subunits of the heterotrimeric G protein. As a result the G protein is no longer able to interact with G protein-coupled receptors (GPCR) on the cell membrane. This inhibits downstream cell signaling.

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