Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP. Concept Introduction: Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

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Answer 1

Question

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

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Answer 2

Question

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

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Answer 3

Question

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

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Answer 4

Question

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

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Answer 5

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

Answer 6

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

Answer 7

Chapter 20, Problem 12P

Interpretation Introduction

Interpretation:

Studies on cAMP actions in cultured cells usually involve adding to the cell culture not cAMP, but dibutyryl cAMP. To explain the need for structural modification of cAMP. Also to understand di-Bu-cAMP has the same biochemical effects as cAMP.

Concept Introduction:

Ligands bind GPCR and activates G protein, which in its GTP bound form activates the cAMP-dependent pathway. GTP bound G protein activates the enzyme adenylyl cyclase which catalyzes the conversion of ATP to cyclic AMP. cAMP activates protein kinase PKA wchih phosphorylates several other proteins.

Answer 8

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Answer 9

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Answer 11

Ch. 20 - Prob. 1P Ch. 20 - Prob. 2P Ch. 20 - Prob. 3P Ch. 20 - Prob. 4P Ch. 20 - Prob. 5P Ch. 20 - Prob. 6P Ch. 20 - Prob. 7P Ch. 20 - Prob. 8P Ch. 20 - Prob. 9P Ch. 20 - Prob. 10P

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