Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 2, Problem 13QP

A cell from a human female has just undergone mitosis. For unknown reasons, the centromere of chromosome 7 failed to divide. Describe the chromosomal contents of the daughter cells.

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Human somatic cells have 46 chromosomes. Are the cells different in any way from the parent cell and what is chromosome count of each of those cells once they have finished mitosis?
Mitotic nondisjunction can occur, particularly in tumor cells. Assume a single nondisjunction event involving the X chromosome occurs in a cell undergoing mitosis in a human female. First, consider the daughter cell with the smaller number of chromosomes: How many total chromosomes will this cell have?  How many X chromosomes will this cell have?    Next, consider the daughter cell with the larger number of chromosomes: How many total chromosomes will this cell have?  How many X chromosomes will this cell have?
Draw and label G1 and G2 stages of interphase and each stage of mitosis (in order) for a cell that has two large and two small chromosomes, 2n=4. For unreplicated chromosome draw a line ( / ) and for replicated chromosome draw an X. Since we are focusing on the DNA, you can skip drawing the nuclear membrane or spindle fibers. For simplicity, do not indicate that the chromosomes are decondensed chromatin during interphase.  Mark and label a place on one of the large chromosomes with the dominant allele of the “A” gene and put the recessive allele “a” on the other homolog. Mark and label a place on one of the small chromosomes with allele “B” and put the recessive allele “b” on the other homolog.

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Human Heredity: Principles and Issues (MindTap Course List)

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