Concept explainers
(a)
To predict: Effect of inhibitor of malate and α-ketoglutarate (n-butylmalonate) on a glycolysis.
Introduction:
Malate-aspartate shuttle is also known as malate-α-ketoglutarate transport system. This transport system is important because the inner mitochondrial membrane is impermeable to NADH (nicotinamide adenine dinucleotide).
(b)
To predict: Effect of inhibitor of malate and α-ketoglutarate transport system (n-butylmalonate) on a oxygen consumption.
Introduction:
The electrons and protons from NADH are transferred to oxaloacetate which forms malate and NAD+. The transporter transport malate across the inner mitochondrial membrane, where it forms oxaloacetate and regenerate NADH.
(c)
To predict: Effect of inhibitor of malate and α-ketoglutarate transport system (n-butylmalonate) on lactate formation.
Introduction:
n-butylmalonate is a chemical compound which inhibits malate and α-ketoglutarate transport system. As a consequence of the blockage of transport system, the transfer of protons and electrons of NADH gets blocked.
(d)
To predict: Effect of inhibitor of malate and α-ketoglutarate transport system (n-butylmalonate) on ATP (adenosine triphosphate) synthesis.
Introduction:
The cells obtain energy in form of ATP by metabolizing carbohydrates, fats, lipids, and proteins. Majorly cells metabolize carbohydrates. Cells are able to carry out aerobic respiration and anaerobic respiration.
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