Microbiology: An Introduction (13th Edition)
Microbiology: An Introduction (13th Edition)
13th Edition
ISBN: 9780134605180
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case, Derek Weber, Warner Bair
Publisher: PEARSON
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Chapter 18, Problem 3CAE
Summary Introduction

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Legionellosis or Legionaries disease is a condition of fever, chills, cough and headache. It causes inflammation and organ involvement are liver, kidney and CNS.  Pneumonia occurs in some patients.

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An elderly man with influenza acquires a case of pneumonia. Gram-positive cocci isolated from his sputum give beta-hemolysis on blood agar. The infection is very difficult to treat. Later, it is shown that the man shared the room with a patient with bone infection. Isolates from both infections were the same. a. Describe 2 biochemical tests that can be used for the definitive diagnosis. b. Describe 2 virulence factors of this pathogen and implicate them in diseases.
Consider the photos here which demonstrate antibiotic sensitivities of Staphylococcus aureus strains as determined by the Kirby-Bauer method. Abbreviations are as follows: C = chloramphenicol; CC = clindamycin; CZ = cefazolin; E = erythromycin; NOR = norfloxacin; OX = oxacillin; P = penicillin; RA = rifampin; SAM = sulbactam-ampicillin; SXT = sulfatrimethoprim; TE = tetracycline; VA = vancomycin. Imagine that only two cellular changes occurred in the original strain (the first image, on the top) that resulted in the resistance pattern of the strain in the second image (on the bottom). Which combination of mechanisms could explainthese results?Choose one or more: A.expression of efflux pumps B.overproduction of PABA C.production of β-lactamase D.altered penicillin-binding protein E.modification of either 50S or 30S ribosomal subunits F.altered DNA gyrase
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