Biology: How Life Works
3rd Edition
ISBN: 9781319017637
Author: James Morris, Daniel Hartl, Andrew Knoll, Melissa Michael, Robert Lue, Andrew Berry, Andrew Biewener, Brian Farrell, N. Michele Holbrook
Publisher: Macmillan Higher Education
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Chapter 17.2, Problem 7SAQ
Summary Introduction
A trait that does not follow the Mendelian law of inheritance is called as complex traits and it is also known as quantitative traits. More particularly, their inheritance is not described by the single gene hereditary segregation. Thus, it can demonstrate a continuous variation range and it can be determined by both genetic and environmental factors.
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Six single-nucleotide polymorphism (SNP) loci are known to contribute to the development of type 2 diabetes. Diabetes is certain if eight or more of the alleles at these six loci are of the “contributing” variety. An uppercase letter indicates an allele that contributes to diabetes and a lowercase symbol indicates a noncontributing allele. A married couple wants to know the probability of producing a child who is at severe risk of type 2 diabetes. Their genotypes were determined by microarray analysis and are as follows:
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