Anatomy & Physiology (6th Edition)
6th Edition
ISBN: 9780134156415
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Textbook Question
Chapter 15.3, Problem 6CYU
Consider the signaling mechanisms of water-soluble and lipid-soluble hormones. In each case, where are the receptors found and what is the result of the hormone binding to the receptor?
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One such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below
1) Provide a brief explanation as to why ligand binding toproteins must be a reversible process.
2) Calculate the dissociation constant (Kd) for the hormone binding to each of the three proteins.
Trace in a stepwise manner the signaling pathway that involves a g-protein receptor leading to the release of intracellular calcium. Specify what class of hormones would be involved in this pathway.
Which of the following is not a true statement?
A.) steroid and thyroid hormone signaling would be impaired if the plasma level of carrier proteins is not optimal.
B.) Steroid and thyroid hormone-receptor complexes form dimers when they bind to the hormone-response elements on DNA
C.) Epinephrine uses the adenylate cyclase and the phospholipase C second messenger systems
D.) signaling by a peptide hormone would be impaired if a second messenger system is not functional in the target cell
E.) signaling by a steroid hormone would be hindered if the adenylated cyclase second messenger system is not functional in the target cell.
Chapter 15 Solutions
Anatomy & Physiology (6th Edition)
Ch. 15.1 - Prob. 1CYUCh. 15.1 - Prob. 2CYUCh. 15.1 - What is the difference between a hormone and a...Ch. 15.2 - Prob. 4CYUCh. 15.3 - Prob. 5CYUCh. 15.3 - Consider the signaling mechanisms of water-soluble...Ch. 15.4 - What are the three types of stimuli that control...Ch. 15.5 - Prob. 8CYUCh. 15.6 - Prob. 9CYUCh. 15.6 - Prob. 10CYU
Ch. 15.6 - List the four anterior pituitary hormones that are...Ch. 15.7 - Prob. 12CYUCh. 15.8 - What is the major effect of thyroid hormone?...Ch. 15.8 - Name the cells that release each of the three...Ch. 15.9 - List the three classes of hormones released from...Ch. 15.10 - Synthetic melatonin supplements are available,...Ch. 15.11 - Which hormone does the heart produce and what is...Ch. 15.11 - Prob. 18CYUCh. 15.11 - MAKING connections Diabetes mellitus and diabetes...Ch. 15.11 - MAKING connections Which of the two chemical...Ch. 15 - The major stimulus for release of parathyroid...Ch. 15 - The anterior pituitary secretes all but (a)...Ch. 15 - A hormone not involved in glucose metabolism is...Ch. 15 - Parathyroid hormone (a) increases bone formation...Ch. 15 - Choose from the following key to identify the...Ch. 15 - Prob. 6MCCh. 15 - Testosterone is to the male as which hormone is to...Ch. 15 - If anterior pituitary secretion is deficient in a...Ch. 15 - If there is adequate carbohydrate intake,...Ch. 15 - Hormones (a) are produced by exocrine glands, (b)...Ch. 15 - Some hormones act by (a) increasing the synthesis...Ch. 15 - Absence of thyroid hormone would result in (a)...Ch. 15 - Medullary chromaffin cells are found in the (a)...Ch. 15 - Atrial natriuretic peptide secreted by the heart...Ch. 15 - Prob. 1SAQCh. 15 - Which type of hormone receptorplasma membrane...Ch. 15 - Prob. 3SAQCh. 15 - Name two endocrine glands (or regions) that are...Ch. 15 - The anterior pituitary is often referred to as the...Ch. 15 - The posterior pituitary is not really an endocrine...Ch. 15 - Endemic goiter is not really the result of a...Ch. 15 - How are they hyperglycemia and lipidemia of...Ch. 15 - Name a hormone secreted by a muscle cell and two...Ch. 15 - We have a new patient to consider today. Mr....Ch. 15 - We have a new patient to consider today. Mr....Ch. 15 - We have a new patient to consider today. Mr....
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- Explain how the hormone-receptor complex can alter theG proteins on the inner surface of the plasma membrane.Which subunit of the G protein alters the activity ofmolecules inside the plasma membrane or inside the cell?arrow_forwardWhich type of hormone receptor—plasma membrane bound or intracellular—would be expected to provide the most long-lived response to hormone binding and why?arrow_forwardIs a hormone altered as a consequence of its interaction with a receptor? Is the receptor altered as a consequence of hormone binding? What are the forces that bind hormone and receptor?arrow_forward
- Visit this link (http://openstaxcollege.org/l/hormonebind) to watch an animation of the events thatoccur when a hormone binds to a cell membrane receptor.What is the secondary messenger made by adenylyl cyclaseduring the activation of liver cells by epinephrine?arrow_forwardWhich statement correctly identifies how a lipid-soluble hormone that diffuses from the blood and through the interstitial fluid identifies which cells in the tissue to act upon? O The cell closest to the diffusion site. O The presence of a receptor located in the cytoplasm or nucleus specific to the hormone in cells. O The presence of a receptor embedded in the plasma membrane of target cells. O The presence of a channel protein embedded in the plasma membrane for the lipid-soluble hormone to diffuse through. Save for Later 80 F3 F4 F5 F6 8 F7 Attempts: 0 of 3 used F8 F9 Submit Answer F10arrow_forwardExplain how mutations in the following proteins might result in either loss of responsiveness to a given hormone or production of a continuous signal even in the absence of the hormone: a mutation in the regulatory (R) subunit of cAMP-dependent protein kinase, making R incapable of binding to the catalytic (C) subunitarrow_forward
- Please identify the incorrect statement about hormone signaling: A) Cystolic receptors bind to hydophobic hormones and transport them into the nucleus where they directly influence protein synthesis. B) Hydropholic hormones cannot pass through the plasma membrane without help. Therefore, there are transport proteins that carry the hydrophillic hormones to the cytosol where it can bind its receptor C) Hydrophilic hormone signalling involves membrane receptors that have the ability to activate adenylyl cyclase, producing cAMP. cAMP then affects the activity of numerous proteins in the cytoplam. D) Hydrophobic hormones easily enter the plasma membrane. Therefore, there is no need for hydrophinic hormone receptors to be on the extracellular surface.arrow_forwardWhy is the fact that a monomeric hormone binds simultaneously to two identical receptor molecules, thus promoting the formation of a dimer of the receptor, considered remarkable?arrow_forwardUnder in vivo conditions, chronic treatment with a noncompetitive antagonist may lead to the up-regulation of the targeted receptor over time. True False Cytokines are peptides that are generally made in advance by specific types of cells, stored in vesicles, and act as autocrine or paracrine factors. True False Thyroid hormone is stored in an extracellular compartment. True Falsearrow_forward
- How does the receptor location differ for lipid- versus water-soluble hormones and why?arrow_forwardRecently, a Gα q-coupled receptor was discovered that mediates at least some of the many activities of estrogen. At the time, this discovery generated considerable controversy, as it ran counter to what was then the understanding of how steroid hormone signaling worked. Which of the following observations might have led the investigators to suspect the existence of this newly discovered receptor? A. Activities of estrogen apparent less than 1 minute after application of the hormone B. The growth promoting activity of estrogen C. The presence of estrogen nuclear receptors in cells not previously known to respond to the hormone D. Estrogen is found in much higher concentrations in adult women than adult men E. Uptake of estrogen by target cellsarrow_forward1) Why are steroid hormones unable to be stored in secretory vesicles? 2) Other than increasing hormone solubility, describe two other consequences of hormones binding to binding proteins.arrow_forward
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