Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 15.3, Problem 1COMQ
How can methylation affect transcription?
a. It may prevent the binding of regulatory transcription factors.
b. It may enhance the binding of regulatory transcription factors.
c. It may attract methyl-CpG-binding proteins, which inhibit transcription, to bind to a methylated sequence.
d. All of the above are possible ways for methylation to affect transcription
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How can methylation affect transcription?a. It may prevent the binding of regulatory transcription factors.b. It may enhance the binding of regulatory transcription factors.c. It may promote the binding of methyl-CpG-binding proteins,which inhibit transcription.d. All of the above are possible ways for methylation to affecttranscription.
Which of the following is true of CpG islands?
a. They are methylated near promoters of actively transcribed genes.
b. They are unmethylated near promoters of actively transcribed genes.
c. Acetylation of CpG islands leads to repression of transcription.
d. CpG islands code for RNA molecules that activate transcription.
fill in the blank:
a. lincRNA plays a role in regulating ___ making genes but they themselves are encoded in the genome that is considered _____ DNA.
b. The most well known example of RNA regulating the expression of DNA is the production of the ___ that coats one copy of the X chromosome in a female forming the ____.
Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 16CONQCh. 15 - Prob. 18CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 20CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 22CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- a. How do bacteria increase the efficiency of gene expression? Is this possible in eukaryotes? b. A mutation in the promoter of Gene K disrupts an enzyme binding site and results in the loss of Gene K expression. Is this change in gene expression likely happening at the transcriptional or the translational level? Explain. c. Propose three different mutations to prevent initiation, elongation, and termination of bacterial transcription, respectively. Explain how/why each mutation would prevent its respective step. (Hint: mutations can be in genes that encode proteins or regulatory DNA sequences)arrow_forwardWhich of the following statements about methylation and acetylation is correct? A. Genes that have hypermethylated (a lot of methylation) promoters are expressed at high levels. B. Deacetylation of histones can lead to a heterochromatin state. C. All nucleotides (CTAG) can be methylated. D. Histones cannot be methylated.arrow_forwardthere is the statement: "Both stem cells and specialized cells have all the same genes. They differ in the regulation of those genes and express very different sets of genes ". Which one of the following explanations best accounts for this difference in stem cell and specialized cell gene expression? A. Stem cells and specialized cells have different activators and repressors that affect transcription B. Stem cells and specialized cells have different promoter sequences for their genes, thus affecting transcription C. Stem cells and specialized cells have different ribosomes that affect translation D. Stem cells and specialized cells use different start codons on mRNAs, thus affecting translationarrow_forward
- How does reverse methylation affect gene expression? Select one: o a. The gene is turned off, but still expresses a protein product. b. The gene becomes transcriptionally silent. c. There is no effect on the gene. d. The gene is hyperactive resulting in a gain of function. e. The gene expresses the wrong protein. Clear my choice How do microRNAs regulate epigenetic mechanisms during development? Select one: o a. MicroRNAs function as gene repressors b. You only find microRNAS in epigenetic and cancer cells c. MicroRNAs function as gene activators d. MicroRNAS regulate methylation on the DNA sequences of embryos e. Researchers find that when microRNAs are present the effects of epigenetic modifications are 50% greater Clear my choicearrow_forwardWhy is regulating transcription the main way that cells control gene expression? A. Because transcription is the last step in gene expression, stopping here ensures that the cell has a stockpile of proteins to prepare them from all unexpected environmental changes. B. Because transcription involves interactions with DNA, preventing transcription reduces the changes of mutation in the cell’s genome. C. Because transcription is the first step in gene expression, stopping at transcription reduces the amount of energy and resources used by producing unnecessary gene products. D. Because transcription is the shortest step in gene expression, preventing transcription has little effect on the rate of protein production.arrow_forward1)A. how do you read a sequence of DNA (template or non-template strand) to convert it an mRNA sequence and to a protein? B.How does chromatin remodeling regulate gene transcription? C. What are the major differences between gene expression in bacteria and eukaryotes D. How are non-coding regions involved in gene transcription? E. Explain how eukaryotic genes sometimes produce multiple protein products?arrow_forward
- Select all of the processes that could be involved in a transcriptional repressor leading to decreased gene expression. a. chromatin remodelling complex responds to tail modification by removing nucleosomes . b. transcription factor binding attracts acetyltransferase enzymes . C. transcription factor binding attracts deacetylase enzymes . D. chromatin remodelling complex responds to tail modification by shifting nucleosomes to a denser grouping. E. DNase cuts the exposed DNA to prevent transcription initiation F. RNA polymerase is unable to recognize the promoter because of the dense chromatin configurationarrow_forwardThe insertion of transposable elements into genes can alter the normal pattern of expression. In the following situations, describe the possible consequences on gene expression.a. A LINE inserts into an enhancer of a human gene. b. A transposable element contains a binding site for a transcriptional repressor and inserts adjacent to a promoter. c. An Alu element inserts into the 3′ splice (AG) site of an intron in a human gene. d. A Ds element that was inserted into the exon of a maize gene excises imperfectly and leaves three base pairs behind in the exon. e. Another excision by that same Ds element leaves two base pairs behind in the exon. f. A Ds element that was inserted into the middle of an intron excises imperfectly and leaves five base pairs behind in the intron.arrow_forwardHow is the expression of genes controlled at the chromosomal level? A. DNA can synthesize extra histones as needed B. DNA can either be condensed into heterochromatin or decondensed into euchromatin C. DNA can be unwound into euchromatin to reduce the level of expression D. The expression of DNA can only be controlled at the transcriptional level E. DNA is spontaneously deleted from a chromosome if not neededarrow_forward
- If a mutation occurred in a control element sequence associated with a particular gene, which of the following would be a likely consequence of this? A. This mutation is not likely to affect the expression of the associated gene, because RNA polymerase does not bind to control elements. B. This will likely affect the expression of the associated gene because it will loosen the coiling of chromatin at this site. C. The expression of the associated gene will be affected because this change will result in a nonsense mutation. D. This mutation is not likely to affect the expression of the associated gene, since control elements are noncoding sequences. E. The associated gene's expression would likely be affected, since this mutation would change the ability of at least one transcription factor to bind.arrow_forwardIs each of the following statements true or false? A. An enhancer is a type of regulatory element. B. A core promoter is a type of regulatory element. C. Regulatory transcription factors bind to regulatory elements. D. An enhancer may cause the down regulation of transcription.arrow_forwardWhich statement/s is/are TRUE about transcription?A. During transcription, DNA polymerase binds to RNA and separates the DNA strands.B. RNA polymerase uses one strand of DNA as a template to assemble nucleotides into a strand of RNA.C. RNA polymerase binds only to DNA promoters, which have specific base sequences.D. Promoters are signals in RNA that indicate to RNA polymerase where to begin transcription.E. Transcription occurs in the 3’ to 5’ direction with respect to the growing mRNA strand.arrow_forward
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