BIOLOGY
BIOLOGY
5th Edition
ISBN: 9781265202859
Author: BROOKER
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Chapter 15, Problem 1TY
Summary Introduction

Introduction: A mutation is a sudden change in the genome of an organism. The change obtained can be hereditary or can be influenced by means of a mutagen. The period of mutagen exposure determines the degree by which an organism is affected.

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Answer to Problem 1TY

Correct answer: A mutation in which there is a removal of single base pair within the coding sequence of a gene and the inactivation of the protein encoded by the gene is called “a frameshift mutation”. Hence, the correct answer is option d.

Explanation of Solution

Reason for correct answer:

The addition and deletion of a single base pair in DNA results in frameshift mutations. In this type of mutation, there is a shifting of the reading frame at the site of mutation which results in the formation of non-functional genes.

Option d. is given as “a frameshift mutation.”

A type of mutation in which there is a deletion of single base pair in the coding sequence of a gene and the inactivation of the protein encoded by the genes is called “a frameshift mutation”. Hence, the correct answer is option d.

Reason for incorrect answer:

Option a. is given as “a silent mutation.”

A silent mutation is a type of point mutation and it does not affect the gene product. Hence, option a. is incorrect.

Option b. is given as “a missense mutation.”

The missense mutations take place by means of base substitutions. Hence, option b. is incorrect.

Option c. is given as, “a nonsense mutation.”

When the process of translation terminates by means of stop codon, the formed protein can be short and nonfunctional. Such mutation is called as nonsense mutation. Hence, option c. is incorrect.

Option e. is given as “both b and c.”

Both missense mutation and nonsense mutation cannot be expressed by the means addition or deletion of nucleotides. Hence, option e. is incorrect.

Hence, the options a., b., c. and e. are incorrect.

Conclusion

A “frameshift mutation” is a mutation in which there is a removal of a single base pair within the coding sequence and the inactivation of the protein encoded by the gene.

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Students have asked these similar questions
A SNV mutation that results in no change in the amino acid sequence is called:  A. silent mutation B. silencing mutation C. missense mutation D. nonsense mutation E. frameshift mutation
A genetic researcher notices that individuals with a particular genetic disease have a shortened version of key protein involved in the diseased biochemical pathway. Which of the following mutations is most likely to result in the premature termination of protein synthesis? A. The disease is caused by a silent mutation. B. The disease is caused by a frameshift mutation. C. The disease is caused by a missense mutation. D. The disease is caused by a nonsense mutation.
Which of the following terms refer to the case when a mutation results in a significant decrease or a complete loss of the functional activity of a gene product? a. gain-of-function mutation   b. loss-of-function mutation
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