Biology: Life on Earth with Physiology (11th Edition)
11th Edition
ISBN: 9780133923001
Author: Gerald Audesirk, Teresa Audesirk, Bruce E. Byers
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 11.5, Problem 1CSC
Summary Introduction
To explain:
Whether most traits are significantly influenced by the environment and by the alleles of other genes that are individual inherits like for example Marfan disease.
Introduction:
The environment has a role in the occurrence of various diseases which includes various factors like polluted water, air, metal toxicity, poor health and hygiene, and effect of ultra-violet and infra-red radiations on the human body. The diseases like cancer are also caused due to the effect of chemicals, radiations and due to infection caused by virus and bacteria.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
A couple enters your genetic counseling clinic for some family planning advice. The woman’s father was color blind, but her own vision is normal. The man has no family history of color blindness. Neither the man nor woman have any known history of hemophilia, but their first child (a boy) has hemophilia. They ask you to calculate the chance that their nextchild will be affected by one or both conditions. You remember from your genetics training that these are both X-linked recessive conditions and that they are closely linked: in fact, their genetic loci are separated by only 10cM! During the interview with this couple, you draw the following pedigree to represent their information. Given what you know, determine for this couple what chance they have of each of the following (in the table).
dominant-therefore someone with AB genotype has AB phenotype. You can see both because
they are codominant)
i) What are the possible genotypes for someone with A blood type?
ii) What about B blood type?
iii) Let's assume that an person by the name of Dustin Beilber (this name sounds
really familiar for some reason) is taken to trial in a paternity suit by a woman
claiming that he is the father of her child. He claims he is not the father. At
the trial, an expert witness reveals the blood types of all three:
Dustin's blood type – B
Mother's blood type – A
Child's blood type – O
Based on these data, is it possible that Dustin is the father of this child? (To put this in terms of
the scientific method, you are trying to disprove the hypothesis that Dustin is the father). If you
can't disprove this, it doesn't mean that he is the father, it simply means that you cannot reject
the hypothesis). Explain your answer.
In individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor the recessive gene. Two normal parents had a daughter with thesymptoms of this disease, and a normal son who marries a normal womanwith an afflicted A test (salt concentration in perspiration of heterozygotes ishigher than normal) disclosed that both are indeed carriers of the gene. If thefirst child born to the mating in (b) was defective, what is the probability thatthe 2nd child would also be defective?Express answer in fraction form
Chapter 11 Solutions
Biology: Life on Earth with Physiology (11th Edition)
Ch. 11.1 - describe the relationships among chromosomes, DNA,...Ch. 11.1 - Prob. 2CYLCh. 11.2 - distinguish between self-fertilization and...Ch. 11.2 - Prob. 2CYLCh. 11.3 - Sudden Death on the court Many traits, in humans...Ch. 11.3 - describe the pattern of inheritance of a trait...Ch. 11.3 - Prob. 1TCCh. 11.3 - Prob. 2CYLCh. 11.3 - Prob. 3CYLCh. 11.4 - Prob. 1CYL
Ch. 11.4 - Prob. 1TCCh. 11.4 - Prob. 2CYLCh. 11.4 - Prob. 2TCCh. 11.4 - Prob. 3CYLCh. 11.5 - Prob. 1CSCCh. 11.5 - Prob. 1CYLCh. 11.5 - Prob. 1HYEWCh. 11.5 - Prob. 1TCCh. 11.5 - explain how polygenic inheritance and...Ch. 11.6 - describe how the patterns of inheritance differ...Ch. 11.7 - Prob. 1CYLCh. 11.7 - explain why most sex-linked traits are controlled...Ch. 11.7 - describe the pattern of inheritance of sex-linked...Ch. 11.8 - Prob. 1CSRCh. 11.8 - use pedigrees to determine the pattern of...Ch. 11.8 - Prob. 1ETCh. 11.8 - Prob. 1TCCh. 11.8 - Prob. 2CYLCh. 11.8 - Prob. 2ETCh. 11 - Prob. 1ACCh. 11 - An organism is described as Rr, with red coloring....Ch. 11 - In certain cattle, hair color can be red...Ch. 11 - Prob. 1MCCh. 11 - Define the following terms: gene, allele,...Ch. 11 - Prob. 2ACCh. 11 - Prob. 2FIBCh. 11 - Prob. 2GPCh. 11 - Prob. 2MCCh. 11 - Prob. 2RQCh. 11 - Prob. 3FIBCh. 11 - Prob. 3GPCh. 11 - Prob. 3MCCh. 11 - Prob. 3RQCh. 11 - Genes that are present on one sex chromosome but...Ch. 11 - Prob. 4GPCh. 11 - Prob. 4MCCh. 11 - Prob. 4RQCh. 11 - Prob. 5FIBCh. 11 - Prob. 5GPCh. 11 - Prob. 5MCCh. 11 - Prob. 5RQCh. 11 - Prob. 6GPCh. 11 - Prob. 6RQCh. 11 - In the couple described in Problem 6, the woman...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?arrow_forwardPART 3– Sex Linkage Hemophilia is a recessive sex-linked disorder in which an important clotting factor protein (Factor VIII) is not produced in a functional form. Queen Victoria was a carrier of the recessive Factor VIII allele, meaning she carried the allele but was asymptomatic. Recently, historians have discovered that she secretly had an affair with the Austrian Count Chocula, who, unbeknownst to her, was a hemophiliac. Naturally, the Royal Family fought to have this information suppressed, but it was revealed that they had many children together. 1. Using the correct allele notation, write the genotypes for Queen Victoria and Count Chocula. 2. In the Punnett Square below, show the cross between the Queen and the Count. P> PĮarrow_forwardSpherocytosis is an inherited blood disease in which erythrocytes (red blood cells) are spherical instead of biconcave. This condition is inherited in a dominant fashion, with ANK1 (the nonfunctional mutant allele) dominant to ANK1+. In people with spherocytosis, the spleen recognizes the spherical red blood cells as defective and removes them from the bloodstream, leading to anemia; this removal occurs with different efficiency in different people. Some people with spherical erythrocytes suffer severe anemia, some have mild anemia, and others do not have any symptoms of anemia. When 2400 people with the genotype ANK1/ANK1+ were examined, it was found that all of them had spherical erythrocytes, 2250 had anemia of varying severity, and 150 had no anemia symptoms. The ANK1/ANK1 genotype is never observed. Which evidence suggests that spherocytosis is incompletely penetrant?arrow_forward
- Spherocytosis is an inherited blood disease in whichthe erythrocytes (red blood cells) are spherical insteadof biconcave. This condition can be inherited in adominant fashion, with ANK1 (the nonfunctional mutant allele) dominant to ANK1+. In people with spherocytosis, the spleen recognizes the spherical redblood cells as defective and removes them from thebloodstream, leading to anemia. The spleen in different people removes the spherical erythrocytes withdifferent efficiencies. Some people with sphericalerythrocytes suffer severe anemia and some mild anemia, yet others have spleens that function so poorly nosymptoms of anemia exist at all. When 2400 peoplewith the genotype ANK1 ANK1+ were examined, itwas found that all of them had spherical erythrocytes,2250 had anemia of varying severity, and 150 had nosymptoms. (Assume that ANK1 ANK1 homozygotesdo not exist.)a. Does this description of people with spherocytosisrepresent incomplete penetrance, variable expressivity, or both? Explain…arrow_forwardBRCA1 is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 protein serves as a key enzyme in repairing DNA double-strand breaks. More than 800 mutations in the BRCA1 are clinically significant. This collection of mutations include missense mutations, small deletions, and large rearrangements that result in a protein with reduced function or no protein product. Inheritance of one mutant allele of BRCA1 is associated with 70-80% lifetime risk of developing breast cancer in females. How is this possible? Select all that apply. The loss of the mutant chromosome during mitosis A point mutation in the allele of BRCA1 inherited from the normal parent Repair of the heteroduplex region containing a mismatch between the normal DNA strand and the mutant DNA strand Nondisjunction of the normal chromosome during mitosis A deletion of the gene copy inherited from the affected parent Mitotic recombination in the region between the BRCA1 gene and the…arrow_forwardX-linked Recessive Inheritance A gene is described as X-linked when it occurs on the X chromosome and not the Y. Our convention is to indicate X-linkage by attaching the appropriate gene symbol as a superscript on the letter X. Commonly, the wild-type (+) allele is indicated with only a "+" to avoid having to type a superscript on a superscript. For example, a female that is heterozygous and carrying a recessive mutant allele is indicated as X+Xm. Note the convenience of the shorthand + for m+ in this situation. A mutant male has the genotype XmY. When working with X-linked inheritance, always include the X and Y chromosomes in the descriptions of genotypes, and include the sex (male or female) in the descriptions of the phenotypes (e.g., mutant male, wild-type female, etc.). Here are the genotypes and associated phenotypes for X-linked recessive inheritance: X+X+ Wild-type female X+Xm Wild-type female xmxm Mutant female X+Y xmy Wild-type male Mutant malearrow_forward
- Dominant negative Incomplete dominance Epistasis Recessive lethal allele III ||| E A condition where one gene has the ability to override the expression of another gene no matter what the relationship is between the other gene's alleles. A condition when a new mutation is able to suppress or revert an earlier mutation allowing wildtype function to reappear. A condition where a recessive allele influences the shape of a protein dimer product in the heterozygous condition so that it neither resembles the homozygous dominant nor the homozygous recessive conditions leading to a LOF in the heterozygous state and the recessive state. A condition where two recessive alleles will be fatal to an offspring although it will not affect aarrow_forwardA female patient 19 years old, whose symptoms areanemia and internal bleeding due to a massive buildupof leukemic white blood cells, is diagnosed withchronic myelogenous leukemia (CML). Karyotypeanalysis shows that the leukemic cells of this patientare heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of thenormal, nonleukemic cells of this patient contain thetranslocation. Which of the following statements istrue and which is false?a. The translocation results in the inactivation (loss offunction) of a tumor-suppressor gene.b. The translocation results in the inactivation (loss offunction) of an oncogene.c. There is a 50% chance that any child of this patientwill have CML.d. This patient is a somatic mosaic in terms of thekaryotype.e. DNA extracted from leukemic cells of this patient,if taken up by normal mouse tissue culture cells,could potentially transform the mouse cells intocells capable of causing tumors.f. The normal function of the…arrow_forwardJunctional epidermolysis bullosa (JEB) is a severe skin disorder that results in blisters over the entire body. The disorder is caused by autosomal recessive mutations at any one of three loci that help to encode laminin 5, a major component in the dermal–epidermal basement membrane. Leena Pulkkinen and colleagues described a male newborn who was born with JEB and died at 2 months of age (L. Pulkkinen et al. 1997. American Journal of Human Genetics 61:611–619); the child had healthy, unrelated parents. Chromosome analysis revealed that the infant had 46 normal-appearing chromosomes. Analysis of DNA showed that his mother was heterozygous for a JEB-causing allele at the LAMB3 locus, which is on chromosome 1. The father had two normal alleles at this locus. DNA fingerprinting demonstrated that the male assumed to be the father had, in fact, conceived the child. Q. Assuming that no new mutations occurred in this family, explain the presence of an autosomal recessive disease in the child…arrow_forward
- a. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? Explain your reasoning. b. Based your answer to part a, give the most likely genotypes for all family members in the pedigree.arrow_forwardTwo mothers give birth to sons at the same time at a busy urban hospital. The son of mother 1 is afflicted with hemophilia. Neither parent has the disease. Mother 2 has a normal son, despite the fact that the father has hemophilia. Several years later, couple 1 sues the hospital, claiming that these two newborns were swapped in the nursery following their birth. As a genetic counselor, you are called to testify. What information can you provide the jury concerning the allegation?arrow_forwardJunctional epidermolysis bullosa (JEB) is a severe skin disorder that results in blisters over the entire body. The disorder is caused by autosomal recessive mutations at any one of three loci that help to encode laminin 5, a major component in the dermal–epidermal basement membrane. Leena Pulkkinen and colleagues described a male newborn who was born with JEB and died at 2 months of age (L. Pulkkinen et al. 1997. American Journal of Human Genetics 61:611–619); the child had healthy, unrelated parents. Chromosome analysis revealed that the infant had 46 normal-appearing chromosomes. Analysis of DNA showed that his mother was heterozygous for a JEB-causing allele at the LAMB3 locus, which is on chromosome 1. The father had two normal alleles at this locus. DNA fingerprinting demonstrated that the male assumed to be the father had, in fact, conceived the child. Q. How might you go about proving your explanation? Assume that a number of genetic markers are available for each chromosome.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
How to solve genetics probability problems; Author: Shomu's Biology;https://www.youtube.com/watch?v=R0yjfb1ooUs;License: Standard YouTube License, CC-BY
Beyond Mendelian Genetics: Complex Patterns of Inheritance; Author: Professor Dave Explains;https://www.youtube.com/watch?v=-EmvmBuK-B8;License: Standard YouTube License, CC-BY