Campbell Biology (10th Edition)
10th Edition
ISBN: 9780321775658
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 11.2, Problem 1CC
Nerve growth factor (NGF) is a water-soluble signaling molecule. Would you expect the receptor for NGF to be intracellular or in the plasma membrane? Why?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
An extracellular signaling molecule binds to cell surface receptor. This cell surface receptor changes shape and activates a trimeric G-protein. What kind of receptor is this?
a) Ion-channel coupled receptor
b) Receptor Tyrosine Kinase
c) G-Protein coupled receptor
d) All of the other answers are correct
e) Enzyme-coupled receptor
Describe the functions of various components of intracellular signaling pathways with diagrams. Explain the three classes of cell-surface receptors.
When activated extracellularly, G protein-coupled receptors (GPCRs) initiate which of the following? (select all that apply)
a G protein signaling mechanism inside the cell.
b) A G protein signaling mechanism outside the cell.
c) Transporters to uptake degraded neurotransmitters for recycling.
d) The release of neurotransmitter molecules into the postsynaptic cell.
Chapter 11 Solutions
Campbell Biology (10th Edition)
Ch. 11.1 - Explain how signaling is involved in ensuring that...Ch. 11.1 - In liver cells, glycogen Phosphorylase acts in...Ch. 11.1 - Prob. 3CCCh. 11.2 - Nerve growth factor (NGF) is a water-soluble...Ch. 11.2 - WHAT IF? What would the effect be if a cell made...Ch. 11.2 - MAKE CONNECTIONS How is ligand binding similar to...Ch. 11.2 - Prob. 4CCCh. 11.3 - What is a protein kinase, and what is its role in...Ch. 11.3 - When a signal transduction pathway involves a...Ch. 11.3 - What is the actual signal that is being transduced...
Ch. 11.3 - WHAT IF? If you exposed a cell to a ligand that...Ch. 11.4 - How can a targct cell's response to a single...Ch. 11.4 - WHAT IF? If two cells have different scaffolding...Ch. 11.4 - Prob. 3CCCh. 11.5 - Give an example of apoptosis during embryonic...Ch. 11.5 - WH AT IF? If apoptosis occurred when it should...Ch. 11 - What determines whether a cell responds to a...Ch. 11 - How are the structures of a GPCR and an RTK...Ch. 11 - What is the difference between a protein kinase...Ch. 11 - What mechanisms in the cell terminale its response...Ch. 11 - What is an explanation for the similarities...Ch. 11 - Binding of a signaling molecule to which type of...Ch. 11 - The activation of receptor tyrosinc kinases is...Ch. 11 - Lipid-soluble signaling molecules, such as...Ch. 11 - Consider this pathway: epinephrine G...Ch. 11 - Apoptosis involves all but which of the following?...Ch. 11 - Which Observation suggestcd to Sutherland the...Ch. 11 - Protein phosphorylation is commonly involved with...Ch. 11 - DRAW IT Draw the following apoptotic pathway,...Ch. 11 - EVOLUTION CONNECTION Identify the evolutlonary...Ch. 11 - Prob. 10TYUCh. 11 - SCIENCE, TECHNOLOGY, AND SOCIETY The aging process...Ch. 11 - WRITE ABOUT A THEME: ORGANIZATION The properties...Ch. 11 - SYNTHESIZE YOUR KNOWLEDGE There are five basic...
Additional Science Textbook Solutions
Find more solutions based on key concepts
Consider the experiment described in Section 2.1 in which Ted Garland and colleagues bred mice to run long dist...
Evolutionary Analysis (5th Edition)
How does the removal of hydrogen atoms from nutrient molecules result in a loss of energy from the nutrient mol...
Seeley's Anatomy & Physiology
More than one choice may apply. Using the terms listed below, fill in the blank with the proper term. anterior ...
Essentials of Human Anatomy & Physiology (12th Edition)
The correct term for production of offspring. Introduction: Reproduction is an important life process for most ...
Biology Illinois Edition (Glencoe Science)
a. What three lineages of lobe-fins survive today? b. Go back to the phylogenetic tree in Interactive Question ...
Study Guide for Campbell Biology
Gregor Mendel never saw a gene, yet he concluded that some inherited factors were responsible for the patterns ...
Campbell Essential Biology (6th Edition) - standalone book
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What distinguishes a steroid receptor from a receptor tyrosine kinase receptor or a G-protein-coupled receptor?arrow_forwardOutline the three general means by which binding of a water soluble extracellular chemical messenger to its matching surface membrane receptor brings about the desired intracellular response.arrow_forwardWhat is the sequence of events that takes place in cell signaling?arrow_forward
- Nerve growth factor (NGF) is a water-soluble signalingmolecule. Would you expect the receptor for NGF to beintracellular or in the plasma membrane? Why?arrow_forwardThe G protein coupled receptor (GPCR) pathway elicits diverse intracellular responses in different cells. The basic steps of GPCR signaling are outlined in this diagram. Which of the following statements correctly describes the process of GPCR signaling? The GPCR activation is reversible after the signal of the ligand diminishes. The membrane-embedded enzyme uses GTP as a secondary messenger to initiate gene expression. The ligand attaches to both the GPCR and the membrane-embedded enzyme to activate the GPCR pathway. The ligand-bound GPCR sends a GTP molecule to an enzyme in the membrane and switches it into an active state.arrow_forwardA mutated form of the α subunit of the heterotrimeric G protein has been identified; this form readily exchanges nucleotides even in the absence of an activated receptor. What would be the effect on a signaling pathway containing the mutated α subunit?arrow_forward
- It is important for the cell to be able to terminate responses, and diminish responsiveness to prevent overstimulation. Cells have different mechanisms for this. One such mechanism is receptor down regulation. a.) Down regulation describes a decrease in the availability of hormones or neurotransmitters that bind to receptors on the surface of target cells, making the cells less likely to be stimulated. b.) Down regulation describes glycosylation of receptor proteins receptors on the surface of target cells in order to decrease the selectivity of ligand binding, making the cells less sensitive to a hormone or neurotransmitter. c.) Down regulation describes a decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or neurotransmitter.arrow_forwardSuppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a receptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?arrow_forwardContinuous exposure of a Gαs protein coupled receptor to its ligand leads to a phenomenon known as desensitization. Describe several molecular mechanisms for receptor desensitization. How can a receptor be reset to its original sensitized state? What effect would a mutant receptor lacking serine or threonine phosphorylation sites have on a cell?arrow_forward
- Name three features common to the activation of cytokine receptors and receptor tyrosine kinases. Name one difference with respect to the enzyme activity of these receptors.arrow_forwardCellular signaling follows a cascade of events and has multiple points of regulation. Which of the following could be a reason(s) why a signalling cascade is interrupted, or turned 'off', once it has been turned 'on'? A) a protein gets tagged with an ubiqutin group and gets degraded B) a chemical modification occurred on serine, threonine, or tyrosine side chains to turn on/off proteins C) allosteric regulation causes an active site to be hidden D) All of the other answers are correct E) The ligand is prevented from reaching the binding sitearrow_forwardIn intercellular signaling pathways, some receptor proteins can also act as a transcription factor (changing gene expression), because these receptors are ________. A) Group of answer choices B) Intracellular receptors C) Membrane bound receptors D) G protein coupled receptors E) Enzyme linked receptors F) Fast ligand-gated ion channelsarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Biology (MindTap Course List)
Biology
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Cengage Learning
Intro to Cell Signaling; Author: Amoeba Sisters;https://www.youtube.com/watch?v=-dbRterutHY;License: Standard youtube license