Concept explainers
(a)
Interpretation:
Synthesis of (S)-1-deutrino-1-propanol should be explained.
Concept introduction:
In the nucleophilic substitution reaction, the
In
Reactant and nucleophile are present at the rate determination step.
The order of species involving in
Tertiary < Secondary < Primary
Example:
Alcohol is reaction with tosyl chloride in pyridine which provides retention of configuration of tosylated compound. This tosylated compound is further reaction with sodium methoxide which undergoes again
(b)
Interpretation:
(S)-1-deutrino-1-methoxypropane should be synthesized.
Concept introduction:
In the nucleophilic substitution reaction, the rate of reaction depends on reactant as well as nucleophile, which are involved in reaction is called bimolecular nucleophilic substitution reaction.
In
Reactant and nucleophile are present at the rate determination step.
The order of species involving in
Tertiary < Secondary < Primary
Example:
Alcohol is reaction with tosyl chloride in pyridine which provides retention of configuration of tosylated compound. This tosylated compound is further reaction with sodium methoxide which undergoes again
(c)
Interpretation:
(R)-1-deutrino-1-methoxypropane should be synthesized.
Concept introduction:
In the nucleophilic substitution reaction, the rate of reaction depends on reactant as well as nucleophile, which are involved in reaction is called bimolecular nucleophilic substitution reaction.
In
Reactant and nucleophile are present at the rate determination step.
The order of species involving in
Tertiary < Secondary < Primary
Example:
Alcohol is reaction with tosyl chloride in pyridine which provides retention of configuration of tosylated compound. This tosylated compound is further reaction with sodium methoxide which undergoes again
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Organic Chemistry, Books a la Carte Edition (8th Edition)
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