Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 10, Problem 19Q
An antimicrobial drug with a _______ therapeutic index is a better choice than one with a ______ therapeutic index.
- a. low; high
- b. high; low
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Which of the following is not a factor that should be considered when selecting a antimicrobial drug?
A. The nature of the microbe causing the infection
B. The overall medical condition of the patient
C. The origin of the drug
D. The degree of susceptibility of the microbe to that drug
Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?
Select one:
a.prophylaxis against infection after a surgical procedure
b.The treatment of strep throat caused by culture identified as Streptococcus pyogenes
c.None of the Above
d.the treatment of a polymicrobial mixed infection in the intestine
e.Empiric therapy (based on educated guesswork) of pneumonia while waiting for culture results
Which of the following medication doses are calculated by using the area under the curve method? A. Carboplatin B. Dacarbazine C. Ifosfamide D. Cyclophosphamide
Chapter 10 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 10.1 - State the main goal of antimicrobial treatment.Ch. 10.1 - Identify the sources for the most commonly used...Ch. 10.1 - Describe two methods for testing antimicrobial...Ch. 10.1 - Prob. 4AYPCh. 10.1 - NCLEX PREP 1. An RN is caring for a 26-year-old...Ch. 10.2 - Explain the concept of selective toxicity.Ch. 10.2 - List the five major targets of antimicrobial...Ch. 10.2 - Prob. 7AYPCh. 10.2 - Distinguish between broad-spectrum and...Ch. 10.2 - Prob. 9AYP
Ch. 10.2 - Explain the mode of action of penicillinases and...Ch. 10.2 - Identify two antimicrobials that act by inhibiting...Ch. 10.2 - Prob. 12AYPCh. 10.2 - Identify one example of a fluoroquinolone.Ch. 10.2 - Describe the mode of action of drugs that target...Ch. 10.2 - Prob. 15AYPCh. 10.2 - Prob. 16AYPCh. 10.2 - Explain why antiprotozoal and antihelminthic drugs...Ch. 10.2 - List the three major targets of action of...Ch. 10.2 - Prob. 2NPCh. 10.3 - Discuss two main ways that microbes acquire...Ch. 10.3 - List five cellular or structural mechanisms that...Ch. 10.3 - Prob. 21AYPCh. 10.3 - Prob. 3NPCh. 10.3 - Prob. 1MMCh. 10.4 - Distinguish between drug toxicity and allergic...Ch. 10.4 - Prob. 23AYPCh. 10.4 - Prob. 4NPCh. 10.4 - Prob. 5NPCh. 10 - Microbial resistance to drugs is acquired through...Ch. 10 - Prob. 2QCh. 10 - Prob. 3QCh. 10 - Prob. 4QCh. 10 - Why does the penicillin group of antibiotics have...Ch. 10 - Prob. 6QCh. 10 - Prob. 7QCh. 10 - Conduct research to find out why drugs blocking...Ch. 10 - Prob. 9QCh. 10 - Prob. 10QCh. 10 - You take a sample from a growth-free portion of...Ch. 10 - Prob. 12QCh. 10 - Treating malarial infections is theoretically...Ch. 10 - Can you think of a situation in which it would be...Ch. 10 - Prob. 15QCh. 10 - Prob. 16QCh. 10 - Prob. 17QCh. 10 - Prob. 18QCh. 10 - An antimicrobial drug with a _______ therapeutic...Ch. 10 - Prob. 20QCh. 10 - Prob. 21QCh. 10 - Prob. 1VC
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- A compound synthesized by bacteria or fungi that destroys or inhibitsthe growth of other microbes is a(n)a. synthetic drug b. antibiotic c. antimicrobial drug d. competitive inhibitorarrow_forwardMicrobial Sensitivity Matching:arrow_forwardBroad-spectrum drugs target a wide variety of bacterial pathogens. Even when the broad-spectrum drug is capable of killing a target pathogen, it may not be the best treatment. Which statement best explains why a broad spectrum drug might be an undesirable treatment choice? Broad-spectrum antimicrobials are usually toxic to the host cells. Broad-spectrum antimicrobials only work if they are used shortly after the infection begins. Broad-spectrum antimicrobials may kill much of the normal microbiota. Broad-spectrum antimicrobials are not able to kill bacteria that are in their log phase of growth. Broad-spectrum antimicrobials may stimulate excess growth of the normal microbiota.arrow_forward
- A physician is treating two different patients. Patient A is being treated with gentamicin (therapeutic index of 3) while patient B is being treated with benzyl penicillin (therapeutic index greater than 100). The initial treatments for both of these patients have failed. Which patient can SAFELY receive a dose increase? A. Patient A B. Patient Barrow_forwardSee picture-- match microbial drug to its action. There can be more than one action per drug.arrow_forwardA broad- spectrum antimicrobial drug would be a drug that attacks many different microbial sites. True or false.arrow_forward
- The clinical effectiveness of a drug majorly depends on: a. Clearance b. Potency c. Affinity to receptors d. Half-lifearrow_forwardPlease choose all the ADVANTAGES of protein-based drugs such as antibodies compare to small molecules from the following options. A. high selectivity B. Biocompatibility C. stable to metabolism D. oral bioavailability E. long half-life F. high activityarrow_forwardThere are many bacterial-antimicrobial resistance combinations. Which one of the following is of maior international concern? a. Sulfonamide resistance in Neisseria meningitides b. Penicillin G resistance in N. gonorrhoeae C. Ampicillin resistance in H. influenza d. Erythromycin resistance in S. pyogenes (group A streptococci) e. Vancomycin resistance in S. aureusarrow_forward
- 1) COVID-19 a. Should there be clinical trails performed by agents (institutions) outside the very drug companies that manufacture them? b. Which factors influence the form of treatment in any given nation (example, amount of moeny, profits to be made, accessibility of the treatment, etc.) c. Which type od approaches you think may work the best in form of minimizing COVID-19 infections and the resulting side effectsarrow_forwardBelow, you can see a picture of an antimicrobial drug. Regarding semi-synthetic antimicrobial drug development to try to avoid development of antibiotic resistance, use 1 sentence to address what is the significance/value of the presence of the various R-groups (e.g. R4, R5, R6, etc.)?arrow_forwardAR is a fair skinned patient who is planning a sunny vacation to the tropics in two weeks. They do not have any allergies or medical conditions and are looking for "maximum protection". They are asking for advice on what they should purchase for insect repellant and sun protection. Which pair of products should be sold to the patient? a. DEET 30% insect repellent/SPF 50 sunscreen b. DEET 99% insect repellent/SPF 50 sunscreen C. natural insect repellent/SPF 15 sunscreen d. DEET 10% insect repellent/SPF 30 sunscreenarrow_forward
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