Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Within a cell, the complete breakdown of glucose to generate ATP occurs by two fundamentally different mechanisms. Name and briefly describe these mechanisms.
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- The number of calories used during physical exercise is greater than the number of calories used for the movements themselves. This may be caused in part by exercise-induced expression of uncoupling protein 1 (UCP1) in subcutaneous fat. Subcutaneous fat is mostly white fat cells but can also contain brown fat cells in mice and humans. As part of a thermogenesis program, UCP1 directly reduces the proton gradient driving oxidative phosphorylation. UCP1 expression is a characteristic of brown fat cells only and is induced by the protein irisin. The data in Table 1 address the relationship between exercise and: in both wild-type mice and mice with overexpression skeletal muscle PGC-1a (a transcription factor whose expression in skeletal muscle is induced by exercise). Table 1 • expression of UCP1 in subcutaneous fat cells, • expression of FNDC5 (a transmembrane protein in skeletal muscle plasma membranes), • blood levels of irisin (a soluble protein formed by cleaving the extracellular…arrow_forwardThe number of calories used during physical exercise is greater than the number of calories used for the movements themselves. This may be caused in part by exercise-induced expression of uncoupling protein 1 (UCP1) in subcutaneous fat. Subcutaneous fat is mostly white fat cells but can also contain brown fat cells in mice and humans. As part of a thermogenesis program, UCP1 directly reduces the proton gradient driving oxidative phosphorylation. UCP1 expression is a characteristic of brown fat cells only and is induced by the protein irisin. The data in Table 1 address the relationship between exercise and: in both wild-type mice and mice with overexpression skeletal muscle PGC-1a (a transcription factor whose expression in skeletal muscle is induced by exercise). Table 1 Effects of Exercise and PGC-1a on UCP1, FNDC5, Irisin, and Adiponectin • expression of UCP1 in subcutaneous fat cells, • expression of FNDC5 (a transmembrane protein in skeletal muscle plasma membranes), • blood…arrow_forwardDescribe the process of cellular respiration, from the introduction of a glucose molecule into the cytoplasm to the production of the final ATP made from energy contained within that glucose molecule.arrow_forward
- List two means by which enzyme activity is directly regulated.arrow_forwardGlycolysis is an important pathway for energy production. As such, the enzymes are always present. After eating a meal, blood glucose levels rise drastically, requiring a rapid increase in glycolytic enzyme concentration to metabolize the influx of glucose. When the blood glucose level drops to baseline, the concentration of glycolytic enzymes is reduced in the cell. Question :- Describe one pathway that allows the cell to rapidly increase glycolytic enzyme levels and one pathway that can be used to reduce glycolytic enzyme levels.arrow_forwardGlucose is degraded into glucose and oxygen is released by respiration in Cows. From where, this glucose comes in Cows? Explain in detail each step of Glycolysis in your own words. Do not draw the Diagram. List enzymes and ATP used and synthesized. Where Glycolysis occurs in cells?arrow_forward
- In each of two steps during the "Energy payoff stage" of glycolysis, ATP is generated when an enzyme uses one of the phosphate groups attached to one of the ends of a 3-carbon intermediate molecule to phosphorylate (add a phosphate group) ADP, forming ATP. This mechanism of producing ATP from ADP and a phosphate group is known as: Question 9 options: substrate level phosphorylation redox phosphorylation lactic acid fermentation oxidative phosphorylationarrow_forward(b) Metabolic state of cells and organism can be associated with inmplication of ATP and NADH. Explain this relationship.arrow_forwardexplain the role adenosine tri phosphate (ATP) and adenosine di phosphate (ADP), play in producing anaerobic and aerobic energy within the body. Identify how much ATP is produced following anaerobic and aerobic metabolism.arrow_forward
- Which of the following conditions will produce active glycogen phosphorylase? AMP АТР Phosphorylation of Serine 14 Glucose Glucose-6-Phosphate Phosphorylation of Serine 14 and AMP Phosphorylation of Serine 14 and ATParrow_forwardDefine the thermodynamic term “work.” Provide two physiological examples of work.arrow_forwardAfter infection, some T cells (a particular type of immune cell) may persist as memory T cells (TMcells). When they re-encounter the same pathogen, TM cells rapidly divide to produce more T cells to help fight off the infection. This rapid cell division requires substantial energy. One way that this energy is provided to TMcells is via increased activity of the ETC. One standard type of experiment for analyzing oxidative metabolism is measuring the oxygen consumption rate OCR in the presence of different compounds. The lines indicate the time at which the different ETC/OxPhos inhibitors were added. Note that the inhibitors are never removed. Complete the table below. Time Period 1 2 3 4 Inhibitor added None Oligomycin (inhibits ATP Synthase) FCCP (Uncoupler) Rotenone + Antimycin (Complexes I and III) Can electrons flow? If so, from which compound to which compound? If not, what is preventing it? Can H+move through the membrane? If so,…arrow_forward
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