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Why does tolerance not develop with drugs that target ion channels
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- Which ion channels are controlled by change in membrane potential? Voltage-gated channels Ligand-gated channels Receptor-operated channels Mechanosensitive channelsWhat kinds of stimuli cause gated ion channels to open or close?How do ion channels that are highly selective obtain high selectivity for that specific ion?
- A student is eating at the lab bench (a clear violation of lab policies) and mistakenly sprinkles tetrodotoxin on his fries. Explain the origin of the toxin and its normal function in that animal. Given that this substance inhibits voltage-gated sodium channels, indicate whether each of the statements below are true or false. Explain your answers. Explain the time course of the response. It will be more difficult for the student’s neurons to generate action potentials The student’s neurons will fire more frequently because membrane potential will be brough closer to threshold. The effect on the membrane potential o the student’s neurons could be predicted by the Nernst equation, which factors in the effects of both ion concentration and ion permeability.Visit this site (http://openstaxcollege.org/l/neurolab) to see a virtual neurophysiology lab, and to observe electrophysiological processes in the nervous system, where scientists directly measure the electrical signals produced by neurons. Often, the action potentials occur so rapidly that watching a screen to see them occur is not helpful. A speaker is powered by the signals recorded from a neuron and it pops each time the neuron fires an action potential. These action potentials are firing so fast that it sounds like static on the radio. Electrophysiologists can recognize the patterns within that static to understand what is happening. Why is the leech model used for measuring the electrical activity of neurons instead of using humans?Indicate where chemically-regulated gated sodium channels are found on the neuron and how they function. Don't copy from Google
- Which of the following statements is true? Chemical messengers within cells are always the main determinant of the effector response. Dual innervation is always present in all organs and glands; one branch enhances the function or secretion, while the other branch inhibits it. The beating of the heart is regulated only by the sympathetic division. Some blood vessels contain alpha adrenergic receptors that cause vasoconstriction in the presence of epinephrine, whereas others have beta adrenergic receptors that cause vasodilation in the presence of epinephrine.A neurotoxin was delivered to a patient that prevented sodium channels from opening at the axon level. How does this affect a neuron's ability to communicate to other neurons? Explain in terms of action potential conductance, and neurotransmitter exocytosis at the axon terminal.Which of the following ion channels are always electrosensitive? stress-activated channels ligand-gated channels with extracellular ligands voltage-gated channels ligand-gated channels with intracellular ligands all of the above