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Why does Neostigmine cause an increase in the twitch tension when the nerve is stimulated and not when the muscle is stimulated?
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Solved in 2 steps
- What are the structural and functional differences between slow and fast muscle?What is the possible mechanism behind the difference between nerve stimulation and direct muscle stimulation?Why does repeated stimulation of the muscle (at maximum stimulus) before it has completely recovered from the previous contraction lead to increasing force of contractions?
- how can you explain twitch recruitment (also called the graded response) when stimulating the muscle versus stimulating the nerve?Why do tetanic contractions indicate the frequency of the nerve impulses causing contractions?What is happening in the muscle during the latent period of a twitch contraction?
- What changes occur within the muscle as a result of increasing frequency of stimulation?What factors determine the duration of an isotonic twitch in skeletal muscle? An isometric twitch?Why might stretching a cramping muscle INCREASE the cramping, as well as why would contracting the opposing muscle rapidly improve the situation?
- In light of the “all or none” law of muscle contraction, how can you explain twitch recruitment (also called the graded response) when stimulating the muscle versus stimulating the nerve? Explain the difference in stimulation voltage required to elicit a maximum response when stimulating the nerve versus the muscle directly?(i) Why does Neostigmine cause an increase in the twitch tension when the nerve is stimulated and not when the muscle is stimulated? (ii) When could Neostigmine be used to treat Myasthenia Gravis?Why is an interneuron needed to provide reciprocal inhibition of the flexor muscle when an extensor muscle is activated?