Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Which of the following is not true about enzymes?
4. Transition state stabilization can significantly increase the activation energy for a reaction.
Nucleophilic groups can catalyze reactions through the transient formation of covalent bonds with the substrate.
Zymogens are the inactive precursors of enzyme.
Enzymes typically act under milder conditions of temperature and pH than non-enzyme chemical catalysts.
Enzyme inhibitors interact reversibly or irreversibly with an enzyme to alter its Km and /or Vmax values.
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- Hi! I would like for someone to help me label the following on the graph below thank youarrow_forward3. Enzyme specificity. To determine the specificity of substrate binding for a particular enzyme/protein, structurally related compounds may be used as potential substrates and Km values may be calculated. However, many compounds structurally related to the substrate may bind to the active site but cannot be converted to product. In these instances, the substrate analogs are used as potential competitive inhibitors of substrate binding. Low K, values indicate high affinity of the enzyme for the inhibitor, whereas high K,values indicate low binding affinity. Consider the enzyme xanthine oxidase, which catalyzes the formation of uric acid from the purine bases hypoxanthine or xanthine in humans. The Km for hypoxanthine is 15.0 μM and for xanthine it is 45.0 μM. A few compounds used as competitive inhibitors of the normal substrate hypoxanthine are listed in the table below with their K; values. Comparing the structures of hypoxanthine with the listed substrate analogs, what can you…arrow_forwardI need helparrow_forward
- 1. Which of the following are general properties of active sites? MARK ALL THAT APPLY. Group of answer choices Multiple interactions with substrate Not very specific Always hydrophobic Small pocket within enzyme.arrow_forward8. Enzyme activity can be registered by one form of covalent modification called phosphorylation. True or false 16. The ionized of all amino acids at pH (7.4) has a net charge of zero. True or false 17. Like beans, eggs would be most likely to be deficient in at least one of essential amino acid. True or falsearrow_forwardPlssssss helppppp, this is a drag and drop.arrow_forward
- Which statement is NOT completely true? O In the Induced-fit theory, the conformation of the active site changes to accommodate an incoming substrate. O A urease which hydrolyzes only urea is an example of an enzyme that exhibits relative specificity. O Cofactors that are organic also go by the name coenzymes O Many enzymes require a second substance present (cofactor) in order to be active. O Enzymes are protein based catalysts. O Enzymes are sensitive to heat and pH O Enzymes catalyze at their "active site". O Apoenzymes are inactive enzymes.arrow_forward1-sketched a graph to show what I think the effect of temperature will be on the rate of reaction (the effect of temperature on enzyme activity) 2-describe in words what you predict the effect of temperature will be on the rate of reactionarrow_forward14. In competitive inhibition, an inhibitor— binds reversibly at the active site. binds to both free enzyme and the ES complex. binds at several different sites on an enzyme. binds only to the ES complex. binds covalently to the enzyme.arrow_forward
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