Which of the following is CORRECT about protein folding? a)The Levinthal paradox demonstrates that proteins must fold randmly b)The Ramachandran plot elucidates the folding rate constant from a first derivative graph c)It is energetically dominated by base pairing interactions d)It probably wouldn’t happen in the presence of significant amounts of organic solvents e_It is always very fast (μs-ms)

Which of the following statements best describe(s) the mechanism by which correct protein folding takes place once the misfolded protein binds the open ring of groEL? Select all that apply.     The groEL ring closes to isolate the protein and provide enough time for the protein to properly fold on its own.     b and d     The groEL ring closes to provide a hydrophilic space to isolate the protein and inhibit its aggregation with others until properly folded.     The groEL ring closes to isolate the protein and provide steric hindrance that mechanically refolds the protein.     The groEL ring closes to isolate the protein and decode the information necessary to achieve the correct three-dimensional structure.     None of the above   I picked "The groEL ring closes to provide a hydrophilic space..." but it was incorrect..

in determining the structure of a fully folded protein? involving the amino acid side chains of the polypeptide. Which has the largest effect 5. hydrogen bonding ionic interactions a) b) c) d) hydrophobic interactions van der Waals interactions none of the above The misfolded, insoluble, and aggregated proteins characteristic of Alzheimer's disease and Parkinson's disease are known as: zymogens b) c) d) e) open quaternary structure proteins protein domains amyloid deposits molecular chaperones 6.

What is the molecular basis for the observation that the overall charge on a protein becomes increasingly positive as pH drops and more negative as pH increases?