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Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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What is the total size of the mature i.e. fully processed mRNA in nucleotides ?
How many amino acids would the encoded protein be? Assume that the N- terminal Met encoded by the AUG start codon, is NOT cleaved from the protein?
![Part B
A hypothetical mouse gene Minnie (Min) has the following gene structure:
A
5',
3'
B
Transcription start
site
5' X₁
5'UTR
202 105
AUG
312
Transcription termination
62
UAG
280
site
3'UTR
3'
5'
(A) 24 3′
The top diagram (A) shows the gene structure of the Minnie gene and the lower
panel (B) shows the mature mRNA generated from that gene by transcription and
splicing, which is exported to the cytoplasm for translation.
In panel A the size of the exons (black) and introns (grey) are given in basepairs.
The location of the transcription start site and transcription termination site are
indicated by the arrows.
In panel B the 5' untranslated region (5'UTR) of the mRNA is 61 nucleotides
(excluding the modified base X at the 5' end) and the 3' untranslated region
(3′UTR) is 127 nucleotides: This includes a 24 nucleotide poly-A sequence added
post-transcriptionally at the 3' end.
NB: You can assume that the poly-A sequence is added to the 3′ end of the third
exon i.e. as defined by the transcription termination site.](https://content.bartleby.com/qna-images/question/ad1bc20b-0a6c-453c-8623-bf53ae851a79/4784beae-5818-4828-a20b-9f1703d1a267/s969sqe_thumbnail.jpeg)
Transcribed Image Text:Part B
A hypothetical mouse gene Minnie (Min) has the following gene structure:
A
5',
3'
B
Transcription start
site
5' X₁
5'UTR
202 105
AUG
312
Transcription termination
62
UAG
280
site
3'UTR
3'
5'
(A) 24 3′
The top diagram (A) shows the gene structure of the Minnie gene and the lower
panel (B) shows the mature mRNA generated from that gene by transcription and
splicing, which is exported to the cytoplasm for translation.
In panel A the size of the exons (black) and introns (grey) are given in basepairs.
The location of the transcription start site and transcription termination site are
indicated by the arrows.
In panel B the 5' untranslated region (5'UTR) of the mRNA is 61 nucleotides
(excluding the modified base X at the 5' end) and the 3' untranslated region
(3′UTR) is 127 nucleotides: This includes a 24 nucleotide poly-A sequence added
post-transcriptionally at the 3' end.
NB: You can assume that the poly-A sequence is added to the 3′ end of the third
exon i.e. as defined by the transcription termination site.
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