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- Describe the contribution of each of the following to establishing and maintaining membrane potential: (a) the Na+K+ pump, (b) passive movement of K+ across the membrane, (c) passive movement of Na+ across the membrane, and (d) the large intracellular anions.Assume that a membrane permeable to Na+ but not to Cl- separates two solutions. The concentration of sodium chloride on side 1 is higher than on side 2. Which of the following ionic movements would occur? a. Na+ would move until its concentration gradient is dissipated (until the concentration of Na+ on side 2 is the same as the concentration of Na+ on side 1). b. Cl- would move down its concentration gradient from side 1 to side 2. c. A membrane potential, negative on side 1, would develop. d. A membrane potential, positive on side 1, would develop. e. None of the preceding is correct.For most neurons, the extracellular concentration of chloride ions (Cl-) is 108 mM, whilethe intracellular concentration of Cl- is 5 mM.If the plasma membrane becomes more permeable to Cl-, would there be Clinflux or Cl- efflux at an RMP of -70 mV? Why?
- If sodium permeability were to increase compared to normal what would be the resulting effect on the membrane potential 1.The charge on the inside of the cell becomes less negative compared to resting conditions and hyperpolarizes 2.The charge on the inside of the cell becomes more negative compared to resting conditions and hyperpolarizes 3.The charge on the inside of the cell becomes less negative compared to resting conditions and depolarizes 4.The charge on the inside of the cell becomes more negative compared to resting conditions and depolarizesChloride ions (Cl-) behave a bit differently to Na+ and K+ in that most cells don't have active Cl- transporters. As a result, the concentration gradient for Cl- is not 'set' like it is for Na+ and K+. There are, however, a limited number of Cl- leak channels in the cell membrane. As a result, Eci generally matches resting membrane potential - around - 70mV. Considering this, answer the following questions. If Cl- can cross the cell membrane, is not being actively transported, and membrane potential is -70mV, will there be a concentration gradient for Cl-?There are differences in Na+, K+, and Cl- ion concentrations across the membrane. Knowing that ions like to flow down their respective concentration gradients explain how the movement of Cl- and K+ ions can result in membrane hyperpolarization.
- What type of ion channel contributes to the restingmembrane potential? Describe the permeabilitycharacteristics of the plasma membrane.Let’s say that the intracellular tonicity is 300 mosm. Checkmark the correct response to what would happen to the cell when it is placed in the following solutions prepared from sucrose (impermeable), NaCl (impermeable), and urea (permeable). Solution Nothing Swell Shrink 100 mM sucrose 200 mM NaCl 300 mM urea 300 mM NaCl 100 mM sucrose + 100 mM NaCl 100 mM ureaThe rapid upstroke of a SA nodal cell action potential is due to the opening of voltage-gated Na+ channels. answer should clearly state whether or not the statement is correct and then concisely explain why. the answer should be 3-5 sentences and address all of the points in the statement. Here is an example: Both transmembrane carrier proteins and transmembrane channel proteins can mediate active transport of a hydrophilic solute through a cell plasma membrane. This statement is incorrect. Movement of a solute through a channel protein is always passive, whereas carrier-mediated transmembrane transport can be either passive or active. A transmembrane channel protein creates a pore through the membrane allowing for simple diffusion of a hydrophilic solute down a concentration gradient through the membrane. In contrast, transmembrane carrier protein interacts with and ‘escorts’ a hydrophilic solute through the membrane and is capable of transporting a solute against a concentration…
- Suppose that certain cells found in an organism are permeable to both CI" and Kt ions but no other ions at rest. The intra- and extracellular concentrations of both ions for these cells are shown below. The resting membrane potential is -75 mV. Assume that passage of both ions across the membrane occurs through ion channels that are selective for each ion. [Intracellular] [Extracellular] CI 4 mM 110 mM K+ 25 mM 100 mM Based on this information, what reasonable conclusion can you draw about the relative permeabilities of K* and CI" ions in these neurons at rest based on what we discussed? а. The membrane is more permeable to chloride ions than to potassium ions at rest. b. The membrane is more permeable to potassium ions than to chloride ions at rest. С. At rest, the membrane potential of these neurons lies closer to the potassium equilibrium potential (EK) than it does to the chloride equilibrium potential (ECI). d. Both a and c е. Both b and cCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane permeable only to Cl−.Below find the structures for ibogaine and cocaine. Ibogaine and cocaine inhibit the dopamine active transporter (DAT). This transporter is a secondary active transporter, and depends on the primary active transporter Na+/K+ ATPase. Ibogaine had a Kι = 2 μM, and cocaine a Kι = 0.64 μM respectively. (a) Define secondary active transport. (b) Is ibogaine an effective treatment for cocaine based on DAT binding?
