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What explains the observation that some forms of porphyria are associated with jaundice while others are not? Some porphyrias, but not all, are due to defects in heme metabolizing enzymes that cause a buildup of bilirubin, which causes jaundice. Some porphyrias, but not all, are due to defects in heme metabolizing enzymes that increase urobilin, which is yellow and concentrated in urine. Some porphyrias, but not all, are due to defects in ABO blood type enzymes that cause a buildup of bilirubin, which causes jaundice. Some porphyrias, but not all, are due to defects in heme metabolizing enzymes that cause a buildup of biliverdin, which is green in color. 271

What explains the observation that some forms of porphyria are associated with jaundice while others are not? Some porphyrias, but not all, are due to defects in heme metabolizing enzymes that cause a buildup of bilirubin, which causes jaundice. Some porphyrias, but not all, are due to defects in heme metabolizing enzymes that increase urobilin, which is yellow and concentrated in urine. Some porphyrias, but not all, are due to defects in ABO blood type enzymes that cause a buildup of bilirubin, which causes jaundice. Some porphyrias, but not all, are due to defects in heme metabolizing enzymes that cause a buildup of biliverdin, which is green in color. 271

Phlebotomy Essentials
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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**Understanding the Link Between Porphyria and Jaundice** Porphyria is a group of disorders characterized by a malfunction in the metabolism of porphyrins, which are compounds crucial for the function of hemoglobin in blood. Some types of porphyria are associated with jaundice, a condition marked by a yellowish tint to the skin and eyes, while others are not. This disparity can be explained by different defects in metabolic processes. **Potential Explanations:** 1. **Bilirubin Buildup:** - Some porphyrias arise from defects in heme metabolizing enzymes, leading to an accumulation of bilirubin. This buildup results in jaundice, as bilirubin is a yellow compound formed from the breakdown of red blood cells. 2. **Urobilin Increase:** - Certain porphyrias involve defects that elevate urobilin levels, which is another breakdown product of hemoglobin. Urobilin is primarily yellow and found in urine. 3. **ABO Blood Type Enzymes:** - Another theory suggests defects in enzymes linked to ABO blood types, causing bilirubin accumulation and subsequent jaundice. 4. **Biliverdin Buildup:** - Some porphyrias might cause a buildup of biliverdin, which is a green pigment. This condition is distinct as biliverdin does not typically cause jaundice characterized by yellow pigmentation. Understanding these explanations is crucial for diagnosing and managing porphyria and its associated symptoms effectively.
Transcribed Image Text:**Understanding the Link Between Porphyria and Jaundice** Porphyria is a group of disorders characterized by a malfunction in the metabolism of porphyrins, which are compounds crucial for the function of hemoglobin in blood. Some types of porphyria are associated with jaundice, a condition marked by a yellowish tint to the skin and eyes, while others are not. This disparity can be explained by different defects in metabolic processes. **Potential Explanations:** 1. **Bilirubin Buildup:** - Some porphyrias arise from defects in heme metabolizing enzymes, leading to an accumulation of bilirubin. This buildup results in jaundice, as bilirubin is a yellow compound formed from the breakdown of red blood cells. 2. **Urobilin Increase:** - Certain porphyrias involve defects that elevate urobilin levels, which is another breakdown product of hemoglobin. Urobilin is primarily yellow and found in urine. 3. **ABO Blood Type Enzymes:** - Another theory suggests defects in enzymes linked to ABO blood types, causing bilirubin accumulation and subsequent jaundice. 4. **Biliverdin Buildup:** - Some porphyrias might cause a buildup of biliverdin, which is a green pigment. This condition is distinct as biliverdin does not typically cause jaundice characterized by yellow pigmentation. Understanding these explanations is crucial for diagnosing and managing porphyria and its associated symptoms effectively.
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