What biological rationale can explain why there are so few variants observed at position 65 of the heme distal ligand and position 94 of the heme proximal ligand of myoglobin? Why does the number of variants differ between the two sites?

What biological rationale can explain why there are so few variants observed at position 65 of the heme distal ligand and position 94 of the heme proximal ligand of myoglobin? Why does the number of variants differ between the two sites?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Related questions

Q: When human hemoglobin undergoes a mutation, the mutant protein usually does not replace all of the…

A: The cytosol of red blood cells contains the oxygen-carrying globular protein hemoglobin, which is…

Q: What type of rotational (cyclic) symmetry is apparent in the structure? O Six-fold. O Seven-fold. O…

A: SARS COV-2 belongs to the coronavirus family. It has many proteins that form the complete structure,…

Q: How do the researchers demonstrate that only diseased blood vessel (affected by atherosclerosis) is…

A: Polyelectrolyte complex micelles are specialized gene delivery vehicles as they can encapsulate the…

Q: a. Panels G, H, and I show pattters wher fluorescence is detected in the cytosol or internal…

A: In the panels G, H, and I, the same β5 subunit of G protein is associated with different γ subunits.…

Q: 2. The two diagrams to the right il- lustrate plots of steady-state ki- netic studies to…

A: Phosphofructokinase adds a phosphoryl group from ATP to Fructose 6 phosphate (F6P) to yield Fructose…

Q: he phylogenetic tree of the OCTN homologs below was generated with the following accession numbers…

A: A phylogenetic tree is defined as a branching diagram which shows the evolutionary relationships…

Q: The Cystic Fibrosis receptor (CFTR) is a transmembrane protein that functions as an ion channel…

A: The compartment where Delta 508 mutation occurs that leads to folding defect in CFTR. This causes a…

Q: Mutational analysis of the important amino acids in the catalytic triad of serine proteases showed…

A: The catalytic triad provides a paradigm for the structural and chemical features of enzymes that…

Q: 16b) Suppose you have a cell in which the Iron Response Factor (IRF) protein is mutated so that it…

A: Iron is a trace element in our body, which is very important to produce hemoglobin which carries…

Q: Genetics of man question:Describe the molecular genetics analysis for the GATA binding protein gene…

A: Genetics helps us understand the underlying causes of diseases and disorders. By studying genetics,…

Q: Predict and explain the effect on GAL1 transcription, in the presence of galactose alone, of the…

A: GAL1 transcript is the mechanism through which RNA polymerase II in eukaryotic cells transforms the…

Q: Normal Hgb is referred to as HbA and contains 4 subunits, 2 α-globin chains and 2 β-globin chains,…

A: The protein structure has different levels:- Primary structure: refers to the normal amino acid…

Q: The diagram below shows the normal sequence of a particular protein, along with several mutant…

A: Original Sequence: Met Gly-Glu-The-Lys-Val-Val- -ProMutant Sequence: Met-GlyMutation Description: In…

Q: Asp48 E(-1) D(-2) H (c) ( To identify the critical enzyme resi- due:substrate interaction and…

A: The parameter is used to define catalytic efficiency of an enzyme. The greater the value, greater…

Q: Crystal structures exist for three neurokinin-1 (NK1) ligand complexes with the following pdb codes…

A: NK1 is a type of mammalian tachykinin receptors. These are G-protein coupled receptors which are…

Q: Which set of fragment ions is likely from the same population of precursors ions (parent peptide)…

A: ANS:- None of the described choices are likely.

Q: 16a) The Iron Response Factor (IRF) is an RNA binding protein that recognizes and binds to a…

A: Iron response element or IRE refers to the stem-loop conserved structure that links to the iron…

Q: What do these data say about the requirements for v-SNARES and t-SNARES in the fusion of vacuolar…

A: As mentioned SNARES are important for membrane fusion of vesicles. v SNARES and t SNARES are…

Q: Cadherins are known to mediate homophilic interactions between cells. What is a homophilic…

A: Cadherins are types of cell adhesion molecules (CAM) these are important in the formation of adheren…

Q: If the serine phoshorylated by Protein Kinase A (PKA) on phosphofructokinase-2 (PFK-2) were mutated…

A: Glucose levels in the blood are maintained by glycolysis (catabolism) and gluconeogenesis…

Q: For each of the 4 regulatory states of the lac operon shown in the following diagram, answer the…

A: Genes active in lactose synthesis are found in E. coli's lac operon. When lactose is present but…

Q: Q1. Explain why GDP cannot dissociate from the alpha subunit of the Trimeric G-protein even though…

A: the G protein coupled receptor is a transmembrane receptor which have seven transmembrane domains ,…

Q: Felal hemoglobin comprises of ay sub-units. has been found that the y-chain contains serine at…

A: 2,3-Disphosphoglycerate (2,3-DPG), promotes the transition of hemoglobin from a high-oxygen-affinity…

Q: Cytosine deaminationoccurs ~100 cytosinesper genome per day in a human genome. Eukaryotic cells…

A: Deamination is the removal of the aminogroup from a base. For example; the deamination of the…

Q: The specific activity of a pure preparation of pyruvate kinase (PK) assayed in the direction of…

A: Pyruvate kinase (PK): The role of pyruvate kinase is to catalyze the final phase of glycolysis,…

Q: While each G-protein subunit has a distinctly characteristic C-terminal sequence that binds certain…

A: G-protein coupled receptors are heteromeric transmembrane proteins. GPCR is activated by specific…

Q: It seems PETT-2 worked better than PETT-1. Examine each structure carefully. Provide plausible…

A: Non-nucleoside Reverse transcriptase (RT) are specific enzymes of HIV-1 RT which serve as drug…

Q: 2- The odorant-binding protein (OBP) was described in rat and cow as a lipocalin that binds odorants…

A: Abstract NGAL (neutrophil gelatinase-associated lipocalin) also known as lcn2 or siderochalin is…

Q: Consider a mutant form of the lac repressor protein whose ΔGo for binding DNA differs from that of…

A: According to thermodynamics, every component of a system possesses free energy. Free energy of…

Q: 33. Band 3 protein exists as a 95-kDa multipass membrane protein that functions as the primary anion…

A: Given, Band 3 protein ,a protein which is essential for RBC membrane support and also acts…

Q: What is the possible consequence(s) of a Q188R mutation for the function of the protein? Keeping…

A: Q188R is one of the common mutations occurring in the gene coding for galactose l-phosphate…

Q: In biochemical and structural terms, how does the cellular form of the prion protein differ from the…

A: There are different macromolecules present in the living organism. Of which proteins are one of the…

Q: . Suggest probable conseauences of the following real or possible hemoglobin mutations. (a) At B146…

A: Mechanism of protein mutation : H146 lies in the alpha/beta interface of the haemoglobin molecule.…

Q: Question is attached

A: The lac operon is an Operon or a collection of genes with a single promoter. The genes in the operon…

Q: (a) Write the reaction in words catalyzed by the enzyme for the alternative substrate, describe how…

A: The enzyme phosphofructokinase-1 catalyzes an important reaction in glycolysis. The reaction…

Q: Genetic testing of a 29-month-old boy shows a mutation in the Phe residue at position 508 in the…

A: Cystic fibrosis is a fatal genetic disease which is caused due to defect in CF transmembrane…

Q: Drug 1-Ivacaftor (VX-770): Ivacaftor is a potentiator that increases CFTR channel opening time. We…

A: The ivacaftor is the most effective for the mutation i.e. deletion

Q: 1) Histone demethylases are important enzymes in epigenetics, and are alpha ketoglutarate-dependent…

A: Histone demethylases control the methylation state at the histone protein also stabilize the…

Q: A) 43 14 When Friend erythroleukemic cells are incubated with sodium butyrate, they differentiate…

A: Introduction : Histones are highly alkaline proteins. They are found in the nucleus of the…

Q: 2 5. The table below shows data on the growth of gly mutants in resp Tricine and Glycine) in…

A: Enzymes are responsible for performing specific chemical reaction by converting the substrate into…

Q: When does a peptide bond form during translation? 1) When the P-site and E-site are occupied by TRNA…

A: mRNA is translated to form protein through the process translation with the help of ribosome, tRNA.…

Q: The Na'vi of Pandora have a neuronal gene (Na'vi) product that undergoes extensive…

A: Transcription occurs in the nucleus. Transcription generates several kinds of RNA from DNA.…

Q: Equation 7a of the text, (max/KM1) [S]-(v'max/KM2) [P] 1+ [S]/KM1 + [P]/KM2 gives the expression for…

A: The following are given in the equation:V represents the rate of the reaction.S represents the…

Q: 1. The shape of hemoglobin binding curves is: hyperbolic or sigmoidal 2. a) Based on the binding…

A: Note: As per the guidelines, i could solve only the first three subparts of the question. Please re…

Q: Specificity in fusion between vesicles involves two discrete and sequential processes. Describe the…

A: Enzymes are biocatalysts that aid in the acceleration of the reaction. They are proteins that serve…

Q: The so-called kelch motif consists of a four-stranded β sheet, which forms what is known as a β…

A: Introduction Proteins are huge biomolecules and macromolecules that are made up of one or more long…

Q: Match the concepts to their definitions or examples. Match each item to a choice: methionine first…

A: DNA is a genetic material that is very stable and almost inert. Even though they are inert and…

Question

Question:-

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Proximal and Distal Histidine of myoglobin

VIEW

Explanation to the answer

VIEW

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

How will the temperature affect the sequence of proteins when ribosome stalling is done in vivo? 2 possible results? how might the temperature affect the sequence of proteins? is there less ribosome stalling at all sites or some locations specifically and why? where is the stalling happening specifically? is there less stalling at all sites or some locations? why might that be? how can raisning the tempreture affect the hydrogen bonds in the ribosome? how can raising the tempreture affect the hydrogen bonds in the ribosome?
Effects of BPA on phosphorylation of MAPKfamily in RAW264.7 cells conclusion
Which phenomenon is not readily explained by the 'induced-fit' hypothesis, that is readily explained by the 'fluctuation-fit hypothesis? Catalysis by optimal interaction with the transition state of substrates. O Specificity of enzymes for substrates. O Lower binding affinity for products, enabling their release once chemistry has happened. O Cooperativity of binding to the remaining 3 sites of hemoglobin when oxygen binds to the first of the four sites.
BL1250 Group activity 4 2020 (1) – Saved to my Mac v Mailings Review View Tell me EXERCISE 4 QUESTIONS 1. TRANSCRIPTION: Much research effort has been invested in understanding how transcription is regulated, because this process is very important for determining cell function. Transcription is a major on/ off switch for genes, providing the instructions for translation and determining the types and amounts of proteins made in a cell at a specific time. The Zebrafish is a model organism for research, and many biologists study how the regulation of genes affects the development of the zebrafish embryo. The effects of a variety of experimental conditions on zebrafish embryos can be easily visualized by light microscopy, because the outer covering (chorion) and the embryo are both transparent. See an images of zebrafish embryos at different time points in development and the adult form below. 0h Os 0.75 h 2h 3.25 h 8 h 16 h 24 h 72 h Adult -3 months (not to scale) Image from:…
Answer asap. Thank you.
Hydrogen bonds are usually 2.7-3.3 angstrom long. According to this information, do you think there is a direct hydrogen bonding between H840 and the phosphodiester bond that links dG13 and dT14 (Chain C)? If not, what is the key role of H840 in Cas9?
GTP-y-s serves as an analog of GTP that cannot be hydrolyzed any further. How would a Co-IP experiment differ between G- alpha & G-beta proteins in the presence of GTP-y-a and GDP?
From experiments in which cells expressing normal myosin II heavy chain were altered to either lack (mhckA-) or overexpress (MHCKA ++) a myosin heavy chain kinase (MHCKA). For answering this question recall the earlier the variants on the myosin II heavy chain, in which three key threonines, normally subject to reversible phosphorylation, were altered in various ways: 3X Ser = Serines in place of Threonines 3X Ala = Alanines in place of Threonines 3X Asp = Aspartate in place of Threonines MHCKA is present at normal levels. Which of the two mutants (mhcp- or MHCP++) would be most likely to have a defect in cytokinesis?
Please help with these quickly.
The mutation in hemoglobin at B82 Lys → Asp results in lowered O,-binding affinity compared to normal hemoglobin. B82 is one of the residues that lines the 2,3-BPG binding site (see Figure 7.29; B82 is adjacent to His143). Based on the location of this residue and the differences between Lys and Asp, sug- gest a rationale for the observed reduction in Oz-binding affinity.
Please help me
a. A single mutation in the riboswitch’s sequence changes the ligand binding specificity from guanine toadenine. Predict what single mutation could be made in the guanine-responsive riboswitch sequenceto convert it to an adenine-responsive riboswitch. Justify your answer b. Could a DNA molecule with the same nucleotide sequence as the guanine-responsive riboswitch bindguanine in a similar manner as the RNA-based molecule? Explain