Voltage-gated K+ channel senses voltage across the plasma membrane and permits selective passage of K+ ions. True False
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Voltage-gated K+ channel senses voltage across the plasma membrane and permits selective passage of K+ ions.
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False
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)Several conserved arginine residues in the voltage-sensor domain allow voltage-gated potassium channels to sense and respond to membrane depolarization. True FalseWhen the membrane voltage shifts from the RMP to a more negative voltage; this is a depolarization repolarization hyperpolarization polarization
- Repolarization occurs because Multiple Choice more sodium ions diffuse into the cell than potassium ions diffuse out of it. potassium ions continue to diffuse out of the cell after the inactivation gates of the voltage-gated sodium ion channels begin to close. the increased potassium ion permeability lasts slightly longer than the time required to bring the membrane potential back to its resting level. the extra efflux of potassium ions causes the membrane potential to become slightly more positive than the resting value. the inactivation gates of the voltage-gated sodium ion channels begin to open and the diffusion of sodium ions decreases.Draw the current that you would expect to flow during a voltage clamp experiment on a typical neuron. Voltages and time course are shown. Briefly explain why the currents are inward or outward. Be sure to provide scale bars. You should definitely label the Y axis so that the peak current value is obvious. Draw the Na+ current you would expect if there were physiological ionic gradients. Draw the K+ current you would expect if there are physiological ionic gradients. Draw the K+ current you would expect if the bath solution and the intracellular solution are both 125 mM.The resting potential of most cells is most dependent concentration gradient of: on the transmembrane Chloride Sodium Potassium Calcium
- Which of the following statements best describes the features of voltage-gated K+ channels? They consist of 4 subunits, are activated at the same time as voltage-gated Na+ channels, but do not inactivate. They consist of 4 subunits, are activated by depolarisation and close slowly during the refractory period. They have 24 membrane spanning alpha helices, 4 of which have positively charged amino acids which promote a conformational change in the channel following depolarisation. They consist of 4 subunits and are open at rest which causes the resting membrane potential to be close to the K+ equilibrium potential.Which of the following are TRUE, when describing the Action Potential of a Non- Contractile Cardiac Pacemaker cell? Select ALL that are true. O Resting membrane potential is more polarized than in neurons, because of more Leakage channels for K+. Progressive Na+ channel (the "funny current", iNa) opening, activates a Transient Voltage Sensitive (T-type) Ca++ channel. Together these channels depolarize the membrane and activate Voltage-Sensitive Long-acting (L-Type) Ca++ channel. The resulting depolarization, closes the "funny" current and T-type Ca++ channels. O Action Potential depolarization, resulting from the Voltage-Activated Na+ channel, triggers Voltage-Sensitive Long-acting (L-Type) Ca++ channel. OMembrane depolarization triggers Voltage-Activated K+ channels (Delayed Rectifier) to open. Increasing K+ permeability and repolarizing the membrane. When the membrane polarizes to -60 mv, the Delayed Rectifier closes and a progressive Na+ channel (the "funny current", iNa) opens. The…Membrane Potential (mV) +35 0 -50 -70 0 A B C | 2 Time (milliseconds) 3 E 4 Use the figure showing phases of the action potential to answer the following question. Most of the voltage-gated sodium channels become open at label ____, and become inactivated at label
- Which of the following statements about voltage gated channels is true? Voltage-gated sodium channels open at a higher (more positive) membrane potential than do potassium-gated channels Voltage-gated sodium channels open at a lower (more negative) membrane potential than do potassium-gated channels Sodium- and postassium-gated channels open at about the same membrane potential, but they have different effects because there are different numbers of the two kinds of channels in neuron cell membranesThe membrane voltage in graded potentials can be produced by Oopen channels and ligand-gated chanels Ovoltage-gated channels Oligand-gated and mechanically gated channels Oligand-gated channels mechanically gated channelsChannel labels Voltage-gated K* channels Voltage-gated Na+ channels Ligand-gated Na+ channels Voltage-gated K* channels lon movement labels K+ exits cell Na+ enters cell K+ exits cell Na+ enters cell Graded potential Depolarization (EPSP) +30 mV -70 Time (msec) +30 mV -70 Depolarization Action potential Time (msec) +30 mV -70 Repolarization Time (msec) +30 mV Hyperpolarization Overshoot -70 Time (msec)