Umar Pharmacy Limited, a pharmacy company claimed that not more than 1% that used its drug experience side effects. To prove its claim, 2500 patients were subscripted with the drugs and only 74 experienced the sides effects. Can the claim by the Umar Pharmacy Limited be accepted at a = 0.05?
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- A quantal dose response data was collected for Drug A to determine ED50. The total number of subjects tested was 100. The equation of the linear portion of the quantal dose-response curve was determined to be y = 0.2316x - 14.337. Calculate the ED50 value for Drug A. Group of answer choices 278 529 420 350A 4 year-old-child weighing 36 pounds will receive amoxicillin oral suspension by mouth every 12 hours. The safe dosing range is 20 - 40 mg/kg/day. What is the maximum safe dose per day in mg? Round to the whole number.Please write/describe at least four criteria that make a target druggable and describe with example the importance of the druggable target that you selected for study (5 points).
- Patient Shirley Temple came in today asking for a refill on her medication for Percocet 10 mg one tablet bid. Your doctor has set in place for you to check every narcotic prescription through e-force. Explain the different things you will find on e Force about the patient and her medication use. Do you think that the e force is useful and do you think that there's a possibility that the e-force could fail and how?The plasma of half-life of aspirin is t1/2 = 20 minutes; ibuprofen t1/2 = 2 hours. Both agents are dosed q 4 to 6 hours. Compared to ibuprofen, APAP's dosing can be much longer than it's plasma half-life because it is: 1. more toxic, so cannot be taken as often 2. more selective for COX1 than is ibuprofen 3. an irreversible inhibitorIn a placebo-controlled study, 10 healthy subjects were given oral triazolam 0.5 mg before and after rifampicin 600 mg daily for 5 days. Rifampicin reduced the triazolam AUC by 95% and decreased its maximum plasma levels by 88%, when compared with placebo. The elimination half-life was reduced from 2.8 hours to 1.3 hours. Pharmacodynamic tests (drowsiness, sway, Maddox wing, etc.) showed that rifampicin abolished the effects of triazolam.a) Why is the AUC of triazolam reduced in the presence of rifampicin? b) Given the above scenario, if you were to accommodate this situation by dosage adjustment strategies, in the presence rifampicin what dose of triazolam would you have recommended, keeping dosage interval the same as when there was no rifampicin? answer part b
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