a placebo-controlled study, 10 healthy subjects were given oral triazolam 0.5 mg before and  after rifampicin 600 mg daily for 5 days. Rifampicin reduced the triazolam AUC by 95% and  decreased its maximum plasma levels by 88%, when compared with placebo. The elimination half- life was reduced from 2.8 hours to 1.3 hours. Pharmacodynamic tests (drowsiness, sway, Maddox  wing, etc.) showed that rifampicin abolished the effects of triazolam. a) Why is the AUC of triazolam reduced in the presence of rifampicin? b) Given the above scenario, if you were to accommodate this situation by dosage adjustment  strategies, in the presence rifampicin what dose of triazolam would you have recommended,  keeping dosage interval the same as when there was no rifampicin?   answer part b

Ideal weight of a child (Table 12.1) is 4.2 kg at 1 month, 5.6 kg at 3 months, 7.7 kg at 6 months, 10 kg at 1 year, 15 kg at 2 years, 18 kg at 5 years and 23 kg at 7 years. The paediatric dose of the opioid analgesic morphine in the APF is 0.1-0.2 mg/kg 2-4 hourly for subcutaneous administration (injection). A 5 year old child, who weighs 18.1 kg requires a 0.11 mg/kg dose of morphine. Calculate the volume of a 10 mg/mL solution that would be required / dose. (Answer to 2 significant figures.)

Clinical Case Study and Med Calculation, Liquids for Injection Aiden Avery, age 54, has a history of Type Il diabetes for 5 years. He is seen in an urgent care clinic for complaints of shortness of breath, nonproductive cough, wheezing, and dyspnea for 1 week. Mr. A is admitted to the hospital to rule out pneumonia. At present, Mr. A has no intravenous access. Medication orders: NPH insulin 10 units subcutaneous daily Regular insulin 15 units subcutaneous daily • Sliding scale insulin: ac (before meals) and at night. For blood glucose greater than 200, administer regular insulin subcutaneously, according to formula: BG-100/40= number of units of regular insulin ● ● ● ● ● ● methylprednisolone 80 mg IVP every 8 hours ticarcillin 750 mg IM now ceftazidime 400 mg IM now morphine 4 mg IM now Calculate the doses (do not round, unless directed): 1. methylprednisolone. Supply: 125 mg in 2 mL Answer 2. ticarcillin. Supply: vial of powder labeled ticarcillin; reconstitute with 2 mL of sterile…

Provide a brief description of the phase 1 clinical trial for Sildenafil (Viagra)? Please reference if possible