tures of Down Syndrome? Development of beta amyloid plaques Abnormal Superoxide Dismutase activity Hyperphosphorylated Tau proteins Misfolded alpha-synuclein proteins
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- Name the misfolded protein associated with each of the following diseases: Alzheimer’s, Huntington’s, Parkinson’s, andtype 2 diabetes.. Suggest the effects of each of the following mutations on the physio- logical role of chymotrypsinogen: (a) R15S (b) Cis (c) T147SDiscuss the significance of the Amyloid Precursor Protein & Superoxide Dismutase in the context of Down’s syndrome.
- GIVE GRAPHICAL MODEL BASED ON GIVEN INFORMATION: There are three elements in this specific model: Alpha Secretase: This node represents the variable or concept of Alpha Secretase, a proteolytic enzyme that cleaves Beta-Amyloid molecules. Beta-Amyloid Formation: This node represents the variable or concept of Beta-Amyloid Formation, which describes the process of the formation and accumulation of Beta-Amyloid protein in the brain. It is regarded as toxic and contributes to the onset of Alzheimer's disease. Calcium signaling: This node represents the variable or concept of Calcium Signaling, which refers to the cellular process involving the regulation and influx of calcium ions. Alzheimer's disease is known to influence calcium signaling pathways. The directed edges in the graph indicate the causal relationships between the variables. The situation: There is a directed edge between Alpha Secretase and Beta-Amyloid Formation, indicating that Alpha Secretase has a direct…Glycogen storage disease type VII or Tarui disease is a rare, autosomal recessive muscularglycogenosis characterized by exercise intolerance, rhabdomyolysis episodes, i.e., disintegration ofmuscle associated with excretion of myoglobin in the urine, and hemolytic anemia, i.e., breakdown ofcirculating erythrocytes with release of hemoglobin into plasma, generally revealed by laboratory tests.The molecular origin of this disease is a deficiency of muscle PFK-1 with a partial deficiency of theenzyme in erythrocytes. Important characterization of the metabolic imbalances associated with thisdisease has been obtained by genetically generating mice with muscle PFK-1deficiency. The histogram diagrams below contrast levels of three glycolytic intermediates in skeletal muscle tissue of wildtype (+/+) normal mice with that in PFK-1 deficient (-/-) mice during rest and exercise. Using thematerial discussed in the previous parts of this question, discuss why lactate concentrations in thePFK-1…A. Elastase is activated by trypsinB. Trypsinisactivatedbyelastase Which statement is correct? Proteolytic activation of chymotrypsin from chymotrypsinogen requires cleavage of four peptide bonds. Assume that any proteases can convert 100 substrates to 100 products. Activation of one enteropeptidase can eventually lead to formation of how many chymotrypsin proteins?
- State the function and desired products of the hexose monophosphate shunt pathway.Regarding cardiovascular disease, match each tern A condition marked by edema of the lungs and shortness of breath, especially when lying down A lesion often seen on the retinal surface (in the eye) of people with diabetes and/or hypertension A triglyceride produced in the liver in response to a high carbohydrate diet that increases chronic disease risk A macrophage that has become engorged with indigestible lipid molecules, leading to inflammation [Choose ] [Choose ] [Choose ] [Choose ] the phrase best describes itcreate or design a concept map explaining in one page using figures, illustrations, and a few descriptions or explanations of the Type 1 glycogen storage disease. The content of your concept map should include the biochemical and molecular basis of the disease with clinical presentation and therapeutic options.
- Increased ROS levels are a hallmark for Alzheimer's Disease. This is accurately described by all but which of the following statements? ROS production is upregulated because of the activity of the enzyme NADPH oxidase Oxidative phosphorylation is increased, leading to enhanced ROS generation via the ETC Amyloid precursor protein is converted in higher amounts to the amyloid peptide facilitating greater amounts of aggregation BACE1 levels are transcriptionally increased via hypoxia inducible factor Mitochondrial pyruvate flux is reduced 00000Describe the causes of proteolytic stress in a living cell.Barth Syndrome describe how it impacts overall cellular function in those afflicted by the disorder?
