To examine: Whether the statement “in the regulation of molecular switches, protein kinases and guanine nucleotide exchange factors (GEFS) always

Need help to understand about the Central Dogma, with questions below.  The Central Dogma What is the big picture? What is the importance of this concept in biology? What are the processes that are controlled or regulated or affected by this concept? Why must these processes be controlled or regulated in the first place?

What would most likely occur to nuclear-cytoplasmic shuttling if the intrinsic GTPase activity of RAN was slowed down by 50%?   Group of answer choices RAN would not bind exportin and proteins would accumulate in the nucleus All of the answers are likely None of the answers are likely Importin beta would not release from RAN in the cytoplasm and nuclear import would slow down RAN would not bind to importin beta and protein cargo in the nucleus would not release

Do you think there are concentration gradients? If so, for which ions are there concentration gradients? Specify whether the concentration values of these ions are higher or lower inside the cell.

Activation of the enzyme protein kinase C results from the binding of (select all that apply): OGq protein Ca²+ DAG IP 3 PIP2 Save for Later

Give a detailed description of how the protein(KRAS) encoded for by your protein normally functions in a cell. What does it do? What does it regulate? Is it an enzyme, transcription factor, regulatory protein, etc.? How does it work?

Epigenetics: Explain DNA methylation. How does this process influence cellular function?

GLUT4 is a protein channel that facilitates the transport of glucose into the cell. Under nor- mal conditions, some of the GLUT4 proteins that are synthesized by the cell do not become active and are instead stored within the membranes of vesicles. The insulin receptor tyrosine kinase (TRK) is a receptor protein that facilitates the decrease of glucose concentration in the bloodstream by increasing the uptake of glucose by cells. When the insulin hormone binds the insulin TRK receptor, a signal transduction pathway causes the activation and addition of GLUT4 to the cell membrane. A model of this signal transduction pathway is illustrated in the figure below. insulin insulin receptor cytoplasm A model of the insulin TRK receptor signal-transduction pathway. Which of the following best predicts the effect of a loss of function of the insulin TRK2 A B C D The stimulation of the signal transduction pathway will increase. The storage of GLUT4 inside the cell will increase. The concentration…

Diagram (just use arrows in the same way you diagrammed in a former test a stimulus leading to the activation of PKC, for example) in as much detail as possible what happens to a mammalian cell when it is irradiated, leading to when the cycle stops due to DNA damage. Include and name the famous mammalian checkpoint protein known by its molecular weight, as well as name another protein it activates. This other protein's function can be described by a 3 letter acronym that contains the letter K. Mention the acronym. 1.

Scaffolding proteins can hold together can permanently hold together signalling pathways.   Question 20 options:   True   False