The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select all that apply.  Drugs should have different mechanisms of action. Each medication should be effective by itself. Toxicity should concentrate in one body tissue. Overlappping toxicity among the agents should be minimal. Each drug should have the same mechanism of action.

In a double blind clinical trial for a drug neither the subjects nor the researcher knows who is in the conrol group or the experimantal group both the experimental and the control group subjects get the drug that is under trial neither the control group nor the experimental group receive the placebo both the groups get placebo and only the researchers are aware of this fact, while both the groups are blinded of this fact both the experimental and control group subjects get placebo and the drug during any part of the study and are not aware of this double test

A COVID treatment combination is Paxlovid: nirmatrelvir and ritonavir. The purpose of ritonavir in this combination is to reduce breakdown of nirmatrelvir. O True False

During clinical trial, which phase only focus on safety but not effectiveness of the tested drug? Phase 0 Phase 1 Phase 2 Phase 3 O Phase 4