The inhibitor X prevents coenzyme Q (Q) from participating in electron transfer in the electrontransport chain.(a) Will the presence of X prevent electrons from NADH from passing through the electron trans-port chain? Explain why or why not.(b) Compound Y is a non-physiological reducing agent capable of directly reducing cytochromecl in Complex III. Would oxygen consumption resume upon the addition of compound Y tomitochondria inhibited by inhibitor X? Be sure to explain your answer.

The mitochondrion is a double membrane bound structure found in eukaryotic cells that is involved in…

Answered: The inhibitor X prevents coenzyme Q (Q)…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Which step(s) of cellular respiration would be directly inhibited by high concentrations of NADH? How would this affect other steps of cellular respiration?
Concerning the use of pyruvate when ratio of NADH/NAD+ is low, what is the fate of the carbon labeled in pyruvate when metabolized under these conditions? a) Production of glucose b) Oxidation to CO2 via the TCA cycle c) Conversion to pyruvate to generate oxaloacetate to move electrons to the cytosol via the malate shuttle d) Pyruvate is never metabolized by the cell, instead pyruvate is converted to lactate and solely exported for the Cori cycle and dependent on the liver to recycle the carbon skeleton
Give all the reactions that will produce ATP either by substrate-level phosphorylation (SLP) or by oxidative phosphorylation (OP). If the given require a shuttle system, please indicate both MA shuttle and GP shuttle and give the ATP produced. Given: fructose 6-phosphate to 2pyruvate
What is the net reaction of the citric acid cycle? What happens to each product? OXIDATIVE PHOSPHORYLATION: 3A) Thoroughly explain the biological significance of NADH/H* and FADH₂ and their roles in oxidative phosphorylation. 3B) Describe and diagram the general pathway of the electrons from NADH/H+ and FADH2 to 02 during the electron transport chain. 3C) What is "chemiosmotic coupling", and what is its relationship to ATP synthesis? 3D) During oxidative phosphorylation, what is oxidized and what is phosphorylated?
Most biochemists agree that the most accurate number of H+ needed to generate one ASP is blank. Therefore one NADH generated about blank ATP molecules?
Assume that 2.5 ATPs are generated per NADH and 1.5 ATPs per FADH2. How many ATPs are generated from the FADH2 and NADH molecules from each repetition of the ββbeta-oxidation pathway? Express your answer as an integer.
If both complex I and complex II send electrons to cytochrome c, how many cytochrome c molecules will it take to deliver those electrons to complex IV? Assume that complex I received one NADH and complex I catalyzed oxidation of one succinate.
Why does FAHD2 oxidation give 1.5 ATP while NADH oxidation gives 2.5 ATP? Explain this in relation to ETC.
Nicotinamide nucleotide transhydrogenase (NNT) in the inner mitochondrialmembrane catalyzes the reaction NADH + NADP+ → NAD+ + NADPH to generate the NADPH needed for certain reactions that help destroy reactive oxygen species. (a) Explain why the NNT reaction cannot be driven primarily by the diff erence in substrate reduction potentials (Δℰ). (b) In fact, the NNT reaction is driven by proton translocation across the membrane (from outside to inside). How does operation of the transhydrogenase aff ect the effi ciency of oxidative phosphorylation?
It is believed that the ratio of cyclic photophosphorylation to noncyclicphotophosphorylation changes in response to metabolic demands. Ineach of the following situations, would you expect the ratio to increase,decrease, or remain unchanged?(a) Chloroplasts carrying out both the Calvin cycle and the reduction ofnitrite (NO2-) to ammonia (This process does not require ATP.)(b) Chloroplasts carrying out not only the Calvin cycle but also extensiveactive transport(c) Chloroplasts using both the Calvin cycle and the C4 pathway
The functioning of a particular pathway often depends not only on control enzymes in that pathway but alsoon control enzymes of other pathways. What happens in the following pathways under the indicated conditions? Suggest what otherpathway or pathways might be influenced.(a) High ATP or NADH concentration and the citric acid cycle.(b) High ATP concentration and glycolysis.(c) High NADPH concentration and the pentose phosphate pathway.(d) High fructose-2,6-bisphosphate concentration and gluconeo genesis.
If actively respiring mitochondria are exposed to an inhibitor of ATPADP translocase, the electrontransport chain ceases to operate. Why?

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