The frequency of an autosomal recessive condition is 0.001 (1 in 1000) in a population. What is the frequency of the mutant allele? Express your answers using three significant figures.
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- Using the two equations, p + q = 1 and p2 + 2pq + q2 = 1, answer the following questions. Maple Syrup Urine Disease (MSUD) is an autosomal recessive condition that causes intellectual and physical disabilities, difficulty feeding, and a sweet maple syrup odor to the urine. In Costa Rica, the incidence of MSUD is calculated as approximately 1 in 8,000 newborns. Calculate the allele frequencies for the normal and disease alleles.Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?The cystic fibrosis allele is recessive. The frequency of cystic fibrosis is 0.000484, or about one in 2000 people. Calculate the allele frequencies. What portion of people are carriers (heterozygotes) for cystic fibrosis?
- A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population? A1A1 = 30 A1A2 = 27 A2A2 = 12 A1A3 = 17 A2A3 = 10 A3A3 = 4 What would be the frequency of the A3A3 genotype? Assume the population is under Hardy-Weinberg equilibrium. A. 0.182 B. 0.27 C. 0.03 D. 0.317 E. 0.107 F. 0.09If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by a rare clinically relevant allele is 1/8500 in a given population, what is the carrier frequency? Please give your answer as a percentage to 3 decimal places, do not include the % symbol. ANSWER: In a population where the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known mutation is 1/8500 the carrier frequency is a percent.The genotype at one CODIS Core Locus for the mother is (3,8) and for the father is (5, 7). Answer the questions below as they relate to that one CODIS Core Locus. Show your calculations and explain your logic. If a forensic profile is (7, 8) for this CODIS Core locus, what is the probability that one of the two sons will match at both alleles and the other will match at just one allele?
- he frequency of an autosomal recessive condition is 0.001 (1 in 1000) in a population. What is the frequency of heterozygous carriers of the mutant allele? Express your answers using three significant figures.If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known clinically relevant allele is 1/8500 in a given population, what is the frequency of the wild type allele? Please give your answer as a percentage to 3 decimal places, do not include the % symbol.Tay-Sachs disease in humans is caused by a recessive allele. The disease is characterized by mental deficiency and blindness, with death occurring by 4 years of age. Among Ashkenazi Jews of central European ancestry, about 1 in 3600 children is born with the disease. Assume Hardy-Weinberg equilibrium and calculate the frequency of the Tay- Sachs allele in this population. Round your answer to the nearest 0.001. Type your answer...
- Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. a. Indicate the gene notation.b. Derive the expected genotypic and phenotypic ratios.c. If they have a normal child, what is the probability that he or she will be heterozygous?d. If they have three children, what is the probability of having 2 affected children and one normalchild?In Sweden 1/500 are born with an autosomal recessive disorder called thalassemia. What is the carrier frequency within the population?Use the following information to answer the next question. Galactosemia is an autosomal recessive disorder. In this disorder, the digestive system is unable to digest the sugar galactose properly. It is a rare disorder that only one in about 30 000-50 000 Caucasian children in North America and Europe are born with. The frequency of the dominant allele in a population of 35 000 children, in which 1 is suffering from galactosemia, is