The first step in glycogenesis is the attachment of a-D-glucose to In this process, glucose 6-phosphate to glucose pyrophosphorylase catalyzes the conversion of 1- phosphate. UDP-glucose the conversion catalyze of into However, glycogen synthase, which linkage, cannot initiate the catalyzes the formation of chain synthesis by using free glucose as an acceptor of UDP to form UDP- glucose. Thus, there is a fragment of glycogen from glycogen stores that are

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway
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Fill in the blanks to make the glycogenesis pathway correct.
The first step in glycogenesis is the attachment of a-D-glucose to
In
this
process,
catalyzes the conversion of
UDP-glucose
glucose 6-phosphate to glucose
pyrophosphorylase
1- phosphate.
the
catalyze
conversion
of
into
However, glycogen synthase, which
linkage, cannot initiate the
catalyzes the formation of
chain synthesis by using free glucose as an acceptor of UDP to form UDP-
glucose. Thus, there is a fragment of glycogen from glycogen stores that are
not totally depleted which will serve as
in cells. In the
can
absence of glycogen fragment, a protein called
serve as acceptor of glucose residues from UDP-glucose. This enzyme then
catalyzes the transfer of glucose from UDP-glucose to the glucosyl chain. This
glucosyl chain will be elongated by
enzyme. Elongation of the glycogen chain includes the transfer of glucose from
UDP-glucose to the
end
of the growing chain.
With the action of branching enzyme,
the
growing chain will be forming a branch thru a 1-6 glycosidic linkage. This
enzyme removes a chain of six to eight glucosyl residues from the nonreducing
end of the glycogen chain, breaking an a (1-4) bond to another residue on the
chain, and attaches it to a non-terminal glucosyl residue by an a (1-6) linkage,
thus functioning as a 4:6 transferase.
Transcribed Image Text:Fill in the blanks to make the glycogenesis pathway correct. The first step in glycogenesis is the attachment of a-D-glucose to In this process, catalyzes the conversion of UDP-glucose glucose 6-phosphate to glucose pyrophosphorylase 1- phosphate. the catalyze conversion of into However, glycogen synthase, which linkage, cannot initiate the catalyzes the formation of chain synthesis by using free glucose as an acceptor of UDP to form UDP- glucose. Thus, there is a fragment of glycogen from glycogen stores that are not totally depleted which will serve as in cells. In the can absence of glycogen fragment, a protein called serve as acceptor of glucose residues from UDP-glucose. This enzyme then catalyzes the transfer of glucose from UDP-glucose to the glucosyl chain. This glucosyl chain will be elongated by enzyme. Elongation of the glycogen chain includes the transfer of glucose from UDP-glucose to the end of the growing chain. With the action of branching enzyme, the growing chain will be forming a branch thru a 1-6 glycosidic linkage. This enzyme removes a chain of six to eight glucosyl residues from the nonreducing end of the glycogen chain, breaking an a (1-4) bond to another residue on the chain, and attaches it to a non-terminal glucosyl residue by an a (1-6) linkage, thus functioning as a 4:6 transferase.
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