The first step in glycogenesis is the attachment of a-D-glucose to In this process, glucose 6-phosphate to glucose pyrophosphorylase catalyzes the conversion of 1- phosphate. UDP-glucose the conversion catalyze of into However, glycogen synthase, which linkage, cannot initiate the catalyzes the formation of chain synthesis by using free glucose as an acceptor of UDP to form UDP- glucose. Thus, there is a fragment of glycogen from glycogen stores that are
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- The binding of insulin to its receptor on the surface of atarget cell activates the receptor’s tyrosine kinase activity,which in turn causes several phosphorylation cascades thatalter the activity of numerous enzymes and alters the expression of genes. Describe how one of these phosphorylationcascades stimulates glycogen synthesis.So for route 1, when OAA decarboxylated to PEP. Are the can immediately converted to pyruvate by enzyme pyruvate kinase or they go completely the gluconeogenesis to product the glucose, and the that glucose break down to pyruvate through glycolysis?phosphofructokinase reaction of Fructose-2,6-bisphosphate is a regulator of both glycolysis and gluconeogenesis for the glycolysis and the fructose-1,6-bisphosphatase reaction of gluconeogenesis. In turn, the concentration of fructose-2,6-bisphosphate is regulated by many hormones, second messengers, and enzymes. Classify each condition according to its effect on glycolysis and gluconeogenesis Activates glycolysis and inhibits gluconeogenesis Activates gluconeogenesis and inhibits glycolysis Answer Bank activation of PFK-2 increased glucagon levels increased levels of cAMP increased levels of fructose-2,6-bisphosphate activation of fructose-2,6-bisphosphatase (FBPase-2)
- АСTVITY 10.8.1 Fill in the blanks to make the glycogenesis pathway correct. The first step in glycogenesis is the attachment of a-D-glucose to In this process, catalyzes the conversion of glucose 6-phosphate to pyrophosphorylase glucose 1- phosphate. UDP-glucose catalyze the conversion of into However, glycogen synthase, which catalyzes the fomation of_ chain synthesis by using free glucose as an acceptor of UDP to fom UDP- _linkage, cannot initiate the glucose. Thus, there is a fragment of glycogen from glycogen stores that are not totally depleted which will serve as absence of glycogen fragment, a protein called , serve as acceptor of glucose residues from UDP-glucose. This enzyme then in cells. In the can catalyzes the transfer of glucose from UDP-glucose to the glucosyl chain. This glucosyl chain will be elongated by enzyme. Elongation of the glycogen chain includes the transfer of glucose from UDP-glucose to the end of the growing chain. With the action of branching enzyme,…Galactose derived from lactose during milk consumption can be metabolized via the glycolytc pathway. Arrange the intermediates of galactose metabolism via glycolysis in order trom the first intermediate to the last intermediato. UDP-glucose Galactose UDPgalactose Galactose 1-phonphateWhich reaction below in the glycolytic pathway has a highly unfavorable delta Gº' but a favorable delta G under physiological conditions? 1,3-Bisphosphoglycerate + ADP3-Phosphoglycerate + ATP O2-phosphoglyerate → phosphoenolpyruvate Ofructose-1,6-bisphosphate dihydroxyacetone phosphate + glyceraldehyde-3-phosphate Ofructose-6-phosphate → fructose-1,6-bisphosphate
- What would be the effect of the Glucagon initiated cascade on inhibition of ATP Synthase by IF1? Metabolic reprogramming in cancer cells correlates to an enhanced expression of IF1. What would be the effect on the TCA? Why might that lead to lactoacidosis?The intermediates of glycolysis with a free energy of hydrolysis sufficient to couple conversion of ADP + phosphate to ATP (a substrate level phosphorylation) include (Choose all that apply) O phosphoenolpyruvate O 2-phosphoglycerate O 1,3-bisphosphoglycerate O glucose-6-phosphate. O fructose-6-phosphate. O fructose-1,6-bisphosphate. O dihydroxyacetone phosphateConsider the following reaction sequence. glucose 1-phosphate + UTP UDP-glucose +-0-P-0- UDP-glucose + (glucose), UDP + (glucose),+1 Which of the following characterizes this process? consumes energy O all of these anabolic O a step in gluconeogenesis
- What is the effect of a defective a(1→ 4) phosphatase in Pompe's disease (GSD II)? O Accumulation of abnormal, unbranched glycogen, leading to heart or liver failure and short fife expectancy O Glycogen accumulation in heart, leading to heart failure, muscle weakness, short life expectancy O Absence of UDP-glucose conversion to glycogen, leading to lack of muscle glycogen, exercise intolerance Glycogen accumulation due to lack of glucose-6-phosphate conversion to glucose, leading to liver enlargement, hypoglycemia, short life expectancy O Lack of complete degradation of glycogen to glucose. leading to mild hypoglycemia, enlarged liver and muscle weakness Submit Request AnswerIf the brain needs glucose, then gluconeogenesis stops after reaction (9, 8, 10, 2) because (phosphoenolpyruvate, glucose, glucose-6-phosphaet, fructose-6-phosphate) can be exported from the hepatocyte using a transporter.In the first stage of glycolysis, fructose-1,6-bisphosphate iscleaved to form glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. The latter molecule can then be converted to glyceraldehyde-3-phosphate. Illustrate themechanisms whereby these reactions occur