The F ab fragment of an antibody molecule has essentially the same affinity for a monovalent hapten as does intact IgG. (a) What is the smallest unit of an antibody that can retain the specificity and binding affinity of the whole protein? (b) Design a compact single-chain protein that is likely to specifically bind antigen with high affinity.
The F ab fragment of an antibody molecule has essentially the same affinity for a monovalent hapten as does intact IgG. (a) What is the smallest unit of an antibody that can retain the specificity and binding affinity of the whole protein? (b) Design a compact single-chain protein that is likely to specifically bind antigen with high affinity.
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter17: Genes And The Immune System
Section: Chapter Questions
Problem 7QP
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The F ab fragment of an antibody molecule has essentially the same affinity for a monovalent hapten as does intact IgG.
(a) What is the smallest unit of an antibody that can retain the specificity and binding affinity of the whole protein?
(b) Design a compact single-chain protein that is likely to specifically bind antigen with high affinity.
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