The average allele frequency will be weighted by the proportion of the allele frequency in males and females: Where: 1 2 p=3 Pm (t) + Pf(t) Pm (t) = the allele frequency in males at time t Pf(t) = the allele frequency in females at time t We also showed the following: Pm (t+1)= pr(t) Pm (t) + pf(t) 2 These are the allele frequencies in males and females at time t+1. Pf(t+1) = Lastly these can be used to determine the genotype frequencies for females in generation t+1 for a sex- linked locus assuming HWE: P₁1(t+1)= Pm (t)pf (t) P12(t+1)= Pm (t)am(t) + am (t)pf (t) P22(t+1)= 9m (t)qf(t) Here is the problem. Consider and X-linked locus with two alleles A1 and A2. Allele A₁ has an initial allele frequency of 1.0 in females and 0 in males. Use a spreadsheet (Excel) and its graphing functions to calculate the allele frequencies in males and females for 25 generations. Also plot the expected genotype frequencies in females for 25 generations. -How long does it take for allele frequencies to reach equilibrium? -How long does it take for female genotypes to reach equilibrium?
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
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