Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Transcribed Image Text:The amino acid arginine has the following forms: H3Arg* pK, =1.82 H2Arg* pK2=8.99 HArg pK3=12.1 e
Arg
What is the principal form of arginine at pH 11.0?
Oa. Arg
O b. HArg
O c. H2Arg
O d. H3Arg-"
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- Titration of alanine by a strong base, for example NaOH, reveals two pk's. Which is the titration reaction occurring at pK1 (pK1 = %3D 2.34)? O-NH2 + COH →-NH + H2O O-COOH + OH →-CO + H20 -COOH + -NH2 → -COO" + -NH2+ -CoO +-NH2* → -COOH +-NH2 O -NH3* + OH →-NH2 + H2Oarrow_forwarda. How many peptide bonds are there? b. How many amino acid residues are there? c. In exact order, identify the name of the amino acids in the peptide chain. d. Give the full name of this peptide. e. Give the 3-letter abbreviation and 1-letter abbreviation. f. Calculate the pI of this peptide.arrow_forwardThe following data were obtained from partial cleavage and analysis of an octapeptide: Composition: Ala, Gly2, Lys, Met, Ser, Thr, Tyr CNBr: (1) Ala, Gly, Lys, Thr(2) Gly, Met, Ser, Tyr Trypsin: (1) Ala, Gly(2) Gly, Lys, Met, Ser, Thr, Tyr Chymotrypsin: (1) Gly, Tyr(2) Ala, Gly, Lys, Met, Ser, Thr N terminus: Gly C terminus: Gly Determine the sequence of the peptide.arrow_forward
- What is the molecular weight of the Botulinum neurotoxin, a protein that contains 1350 amino acids? Assume an average distribution of amino acidsarrow_forwardWhich of these amino acids is a polar, uncharged amino acid? (Select all that apply, if necessary.) A. B. D. E. CHLO H₂N-CH-C CH₂ CH₂ CH₂ NH C=NH2 NH₂ amino acid A amino acid C amino acid D amino acid B amino acid E H₂N-CH-C CH₂ _i_g C. H₂N-CH-C- CH2₂ I CH₂ =0 NH₂ H₂N-CH- CH₂ CH-CH3 CH3 H₂ND H₂N-CH- | CH₂ Ï OHarrow_forwardDraw the L enantiomer in a Fischer projection for each amino acid; identify the amino acid as neutral, acidic, or basic. Give the three-letter sign [3], and the one-letter symbol [4].arginine a. arginine b. arginine c. a. glutamic acid b. glutamic acid c. glutamic acidtyrosine b. valine c. argininearrow_forward
- Patients suffering from sickle cell anemia have a mutation in the gene that codes for one of the hemoglobin chains, in which a single glutamate is replaced by a valine. Propose an explanation for why this substitution has such a striking effect on protein structure and function with explanation. Suggest two other amino acids that would be less likely to cause such serious impairment of hemoglobin function if each was substituted for glutamate. Briefly explain your answer.arrow_forwardYou are given a protein solution with a concentration of 0.15 mg/ml. Suppose that we want to prepare a solution containing 100 μg of the protein at a concentration of 1 mg/ml. To achieve this, we will first dry down enough protein solution to obtain 100 μg of proteins. How much solution do we need for drying down? How much volume of H2O do we need to add to the dried protein to obtain the desired concentration?arrow_forwardWhich of the following catalyzes reactions that incorporate nitrogen derived from glutamine? a) Glutamine synthase b) Glutamine amidotransferase c) Adenylyltransferase d) Glutamate synthasearrow_forward
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