Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
Bartleby Related Questions Icon

Related questions

Q: Can you help me the name of the brain with the blood of the labels?
A: The mass of nerve tissue in the anterior edge of an organism is the Brain. The brain integrates…
Q: CN12 Hypoglossal
A: The twelve pairs of nerves that arise from the brain and function to connect the brain with several…
Q: Muscle Mass and Weight Lifting OPositive O Negative O Zero
A:
Q: بار در انبار الدولة ر
A: The ECG or electrocardiogram is a test that is used to detect the heart rhythm and electrical…
Q: stroke & Normal pregnacy( antenatal monitoring)
A: Stroke is a medical condition that occurs when the blood supply to part of the brain is interrupted…
Q: Body symmetry: Drawing of organism: #5 Distinctive features: Domain: but ri to consider that all…
A: Sponges are multicellular organisms that are studied under spongiology. They are heterotrophic…
Q: Medications for diabetes
A: Diabetes Mellitus: Diabetes is a chronic medical condition characterized by high levels of glucose…
Q: FRONT DE ONLY 9.
A: The liver is one of the large organs in the body that is situated in the right upper abdomen just…
Q: Mr. Johnson is 6'3" tall.when you record an EKG, you must record his height in inches. How many…
A: Documentation plays a crucial role in recording ECG of the patient. We as Nurses need to active…
Q: Identify # 50 50.
A: Central nervous system includes brain and spinal cord. It is formed by neurons and supporting cells…
Q: 皮
A: Skeletal system is a body system which form structural framework around the body and helps in…
Q: A
A: The parathyroid gland is a small but major endocrine gland present in the neck of humans. Humans…
Q: III IV VI VII
A: The kidneys are bean-shaped organs that filter blood. It is made up of millions of nephrons which…
Q: differences between AKI vs CRK
A: Kidneys are the major excretory organs located in the retroperitoneal space. One kidney is located…
Q: Identify #4 3 1 2
A: The diagram represents the larynx. The larynx is a muscular tube found just below the pharynx. The…
Q: In The Day of the Triffids, after most people in the world are blinded by an apparent meteor shower,…
A: The alleles are generally of dominant and recessive type and some other forms like codominant are…
Q: PERSON CENTER PLAINING .
A: Person-Centered Planning (PCP)  - is an approach, designed to empower, and involve individuals in…
Q: Definition of IP3
A: Cell signaling is the process of communication between cells. It occurs with the help of various…
Q: Gluconeogenesis uses just the carbon skeleton of amino acids, not fatty acids. So, how does fatty…
A: Gluconeogenesis can be described as the de novo synthesis of glucose from nonhexose precursors,…
Q: 1. How might BMI information be useful to individuals? 2. Is BMI information alone enough for…
A: Body composition is the percentage of fat and non-fat mass in your body.  The body composition of a…
Q: how do you know if the duiretic was effective
A: Diuretics are drugs that prevent the reabsorption of water from kidney tubules and thereby increase…
Q: What do the palmar arches supply blood to? One word.
A: The human circulatory system is responsible for the circulation of blood through the body. It is…
Question
3
10:16 AM Fri Sep 2 < то 1. A simplified structure of the peptide Lys-Glu-Ser with just the ionizable groups in the charged state is shown with the pKa of each group. Calculate the pl for this peptide. Show your work. pka = 8.5 H3N+ NH3* pKa 10.0 2. Draw a dipeptide with a trans linkage and a net charge of -1 at pH 7 a. Indicate which six atoms are part of the planar structure of the peptide bond. b. Is the Cis or Trans linkage of a peptide preferred? Why? COO- OH pka=4.2 3. A mutation that changes an alanine residue in the interior of a protein to a valine is found to lead to a loss of activity. The activity is regained when a second residue is mutated from an isoleucine to a glycine. Why would this mutation restore activity? 5. Tetrahydrofuran, THF, a water-soluble ether, has a lower dielectric constant (less polar) than water. When THF is added to an aqueous solution of a protein, would you expect the a-helix content of the protein to increase or decrease. Why? 6. Given the following three amino acid sequences: 7. What is SDS and what is its purpose in gel electrophoresis? +: 4. The proteases chymotrypsin and trypsin cleave on the C terminal side of Phe and Arg respectively. During purification, one must be more careful with trypsin since it is known to cleave itself much more readily than chymotrypsin. Why? Peptide # 1: Val-Phe-Val-lle-Val-Pro-Gly-Tyr-Val-Phe-Leu-Val-Pro-Gly-Val Peptide # 2: Met-Ala-Glu-Ala-Glu-Ala-Ala-Met-Lys-Lys-Ala-Ala-Met-Lys Peptide # 3: Pro-Gly-Ala-Pro-Gly-Ala-Pro-Gly-Gly-Pro-Gly-Pro-Ala-Gly-Pro a. Which peptide is most likely to form an a-helix? Explain pka = 3.5 COO- @83% b. Which peptide is most likely to form a ß-sheet? Circle the most likely residues involved in the turns of the ß-sheet on the peptide your chose above. c. What is the net charge of Peptide #2 at pH 14? (113 +
expand button
Transcribed Image Text:10:16 AM Fri Sep 2 < то 1. A simplified structure of the peptide Lys-Glu-Ser with just the ionizable groups in the charged state is shown with the pKa of each group. Calculate the pl for this peptide. Show your work. pka = 8.5 H3N+ NH3* pKa 10.0 2. Draw a dipeptide with a trans linkage and a net charge of -1 at pH 7 a. Indicate which six atoms are part of the planar structure of the peptide bond. b. Is the Cis or Trans linkage of a peptide preferred? Why? COO- OH pka=4.2 3. A mutation that changes an alanine residue in the interior of a protein to a valine is found to lead to a loss of activity. The activity is regained when a second residue is mutated from an isoleucine to a glycine. Why would this mutation restore activity? 5. Tetrahydrofuran, THF, a water-soluble ether, has a lower dielectric constant (less polar) than water. When THF is added to an aqueous solution of a protein, would you expect the a-helix content of the protein to increase or decrease. Why? 6. Given the following three amino acid sequences: 7. What is SDS and what is its purpose in gel electrophoresis? +: 4. The proteases chymotrypsin and trypsin cleave on the C terminal side of Phe and Arg respectively. During purification, one must be more careful with trypsin since it is known to cleave itself much more readily than chymotrypsin. Why? Peptide # 1: Val-Phe-Val-lle-Val-Pro-Gly-Tyr-Val-Phe-Leu-Val-Pro-Gly-Val Peptide # 2: Met-Ala-Glu-Ala-Glu-Ala-Ala-Met-Lys-Lys-Ala-Ala-Met-Lys Peptide # 3: Pro-Gly-Ala-Pro-Gly-Ala-Pro-Gly-Gly-Pro-Gly-Pro-Ala-Gly-Pro a. Which peptide is most likely to form an a-helix? Explain pka = 3.5 COO- @83% b. Which peptide is most likely to form a ß-sheet? Circle the most likely residues involved in the turns of the ß-sheet on the peptide your chose above. c. What is the net charge of Peptide #2 at pH 14? (113 +
Expert Solution
Check Mark
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
bartleby
This is a popular solution
See solutionCheck out a sample Q&A here
Step 1
VIEW
Step 2
VIEW
Step 3
VIEW
bartleby

Trending nowThis is a popular solution!

bartleby

Step by stepSolved in 3 steps

See solution
Check out a sample Q&A here
Blurred answer
Knowledge Booster
Background pattern image
Similar questions
Recommended textbooks for you
Text book image
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Text book image
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Text book image
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Text book image
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON
SEE MORE TEXTBOOKS