The addition of new nucleotides to a growing polynucleotide strand occurs in a ___. a) 53 direction on the lagging strand, and 35 direction on the leading strand b) 5 3 direction c) amino-carboxy direction d) 53 direction on the leading strand, and 3-5 direction on the lagging strand e) 3-5 direction Question 100 (Mandatory) Micro RNA, siRNA, anti-sense RNA are all able to prevent the use of a processed mRNA. What level gene regulation event is this? a) chromatin b) transcription c) post-translation d) translation

Which level of protein structure would be most affected by the following changes... a) mutation from isoleucine to valine b) oxidation of two cysteine sidechains c) PrP (healthy prion protein, mostly a-helical) changes to PrP (infectious form, mostly ß-strand) (more than one answer!) d) increase in pH from 7 to 10

Replication slippage can cause indels in repetitive regions of DNA. Which of the following statements is not true?a) slippage of the new daughter strand causes repeat expansionb) slippage of the template strand causes repeat deletion c) slippage can cause indels on either the daughter or the template strandd) the indel mutation becomes fixed in one daughter cell's genome only after the next round of replication e) none of the above (all are true statements)

During DNA replication the bond between the growing strand and the incoming nucleotide is formed between the phosphate group of the nucleotide being added and the of the last nucleotide in the polymer. a) a nitrogen from the nitrogen containing base b) the fifth carbon c) the 5' phosphate d) the 3' OH